kidd, kell, lutheran BGS

Question 1

how many weeks to detect Jk a

a. 11 weeks
b. 7 weeks
c. 8 weeks
d. 2 weeks

Answer 1

JKa and JKb

• commonly found in RBC of most individuals
• detected on fetal rd cells as early as 11 weeks for JKa
  and 7 weeks for JKb
• not altered by enzymes

Question 2

which of the bgs has a notorious reputation in blood bank

a. kidd
b, duffy
c. lutheran
d. P

Answer 2

answer : Kidd

kidd antibodies have a NOTORIOUS REPUTATION IN BLOOD BANK

Question 3

which of the bgs is most common cause of DHTR

a. kidd
b, duffy
c. lutheran
d. P

Answer 3

answer: kidd

anti JKa and anti JKb
- they are immune antibodies amde to response to PREGANCY OR TRANSFUSION

• The decline in antibody reactivity and the difficulty in detecting Kidd antibodies are reasons why they are a common cause of HTRs, especially of the delayed type

✓ Most Common cause of DHTR (delayed hemolytic transfusion reaction)

✓ Contrary to their hemolytic reputation in transfusion, most Kidd antibodies are only rarely associated with severe cases of HDFN

Question 4

Ingestion of Methyldopa will lead to Autoab formation directed to what BGS

a. kidd
b, duffy
c. lutheran
d. P

Answer 4

Drug Induced Autoantibody (auto ab kidd)

✓ Associated with KIDD BGS on patient receiving ALDOMET/METHYLDOPA and another was chlorpropamide-dependent

Question 5

_______resists lysis in 2M urea

a. Jk(a-b-)
b. Jk(a+b-)
c. Fy (a-b-)
d. Fy(a+b-)

Answer 5

Jk(a-b-) resists lysis in 2M urea

Jk(a+b+) LYSED in 2M urea

Question 6

it was the first blood group system discovered after the introduction of antiglobulin testing.

a. kidd
b, duffy
c. lutheran
d. Kell

Answer 6

Kell

Question 7

3rd most important BGS

a. kidd
b, Kell
c. lutheran
d. P

Answer 7

1st - ABO
2nd - Rh
3rd - Kell

Question 8

k antigen can be detected on fetal bc as early as __

a. 11 weeks
b. 6 weeks
c. 10 weeks
d. 5 weeks

Answer 8

The K antigen can be detected on fetal RBCs as early as 10 weeks and is well developed at birth.

Question 9

The Kell glycoprotein is covalently linked with another protein, called ___,

a. Anti - LW
b. oH
c. XK
d. aota

Answer 9

The Kell glycoprotein is covalently linked with another protein, called Xk, by a single disulfide
bond.

Kell antigen expression is dependent upon the presence of the Xk protein

Question 10

absence of XK result in _____

a. infectious mononucleosis
b. Mc Leod syndrome
c. Mycoplasma pneumoniae
d. PNH

Answer 10

The absence of Xk results in McLeod syndrome. It is also associated with CGD (Chronic granulomatous disease)

Infectious mononucleosis
- Anti - i

Mycoplasma pneumoniae
- Anti I

Paroxysmal nocurnal hemoglobinuria
-antii - i

Question 11

Kpb

a. penny
b. rautenberg
c. cellano
d. matthews

Answer 11

-K (Kell), 
k (Cellano), 
Kpa(Penny), 
Kpb(Rautenberg),
 Jsa(Sutter),
 Jsb(Matthews)

Question 12

depressed Kell antigen are seen on RBCs witth rare

a. hodgkins lymphoma
b. leach phenotype
c. CGD
d. Mc leod syndrome

Answer 12

• Depressed Kell antigens are seen on RBCs with the rare Gerbich-negative phenotypes Ge: –2, –3, 4 and Ge: –2, –3, –4.(leach phenotype)
• Patients with AUTPIMMUNE HEMOLYTIC ANEMIA, in which the autoantibody is directed against a Kell antigen, may have depressed expression of that antigen.

Question 13

most common antibody can be seen in bloodbank

a. anti JK
b. alloanti - JK3
c. anti- K
d. anti Fya

Answer 13

anti-K is the most common antibody seen in the blood bank

Question 14

anti - K can seen in serum of what individual

a. KK
b. kk
c. Kk
d nota

Answer 14

b.kk

Question 15

what BGS is 2nd to D in terms of immunogenicity

a. kidd
b. duffy
c. kell
d. lutheran

Answer 15

excluding ABO, K is rated as SECOND ONLY TO D IN TERMSOF IMMUNOGENICITY

Question 16

LACK OF EXPRESSION OF KELL ANTIGENS

A. Kx antigen

b. Ko phenotype
c. Anti - Ku

Answer 16

Ko phenotype

- Ko RBCs LACK OF EXPRESSION of all Kell antigens

Question 17

which of the following is low frequency Kell antigens

a. Kpa
b. k
c. Jsa
d. Jsb

Answer 17

Antibodies to Kpa ,Jsa ,and other low frequency Kell antigens

     - exposed to the antigen
    - Most often detected through unexpected incompatible cross-matches or cases of HDN

Antibodies to k, Kpb , Jsb ,and other High frequency Kell antigen
- Antibodies to high frequency Kell antigens are rare, because so few people lack the antigen

Question 18

what BGS does blood bankers seldom deal

a. kidd
b. kell
c. duffy
d. lutheran

Answer 18

Lutheran BGS

• Blood bankers seldom deal with the serology of the Lutheran blood group system.

Question 19

HDFN is rare and only mild at birth

a. Lutheran
b. MNS
c. Kell
d. Duffy

Answer 19

answer: Lutheran BGS

Lua and Lub

• HDFN is rare and only mild at birth
• Lutheran glycoprotein on placental tissue may result in adsorption of maternal antibodies to Lutheran antigens, thus decreasing the likelihood of HDFN

Question 20

whichof the antibody of Lutheran is IgG

a. Anti - Lua
b. Anti Lub
c. Anti Lu3
d. nota

Answer 20

Anti-Lua

✓ Most are naturally occurring saline agglutinins (IgM) that react better at room temperature than 37’C

✓ Experienced technologists recognize Lutheran antibodies by their characteristic loose, mixed-field reactivity in a test tube

Question 21

which of the bgs has a chaacteristics is losse, mixed ield reactivity on test tube

a. Anti - Lua
b. Anti Lub
c. Anti Lu3
d. nota

Answer 21

Anti-Lua

✓ Most are naturally occurring saline agglutinins (IgM) that react better at room temperature than 37’C

✓ Experienced technologists recognize Lutheran antibodies by their characteristic loose, mixed-field reactivity in a test tube

Question 22

Implicated with shortened survival of transfused cells and post transfusion jaundice

a. Anti - Lua
b. Anti Lub
c. Anti Lu3
d. nota

Answer 22

Anti-Lub

• Most are IgG although IgM and IgA antibodies have been noted
• Implicated with shortened survival of transfused cells and post transfusion jaundice