minor bgs Flashcards
Wra
a. diego
b. cartwright
c. XG
d. Scianna
ISBT 010 DIEGO
Antigens: Dia /Dib and Wra Wrb , Wda, Rba, WARR
- Dia useful tool in ANTHROPOLOGIC MONGOLIAN ANCESTRY
- located : AE 1 (anion exchange molecule)
- associated : HEREDITARY SPHEROCYTOSIS. ACANTHOSIS , OVALOCYTOSIS
Antibodies: Both ______________are IgG antibodies reactive in IAT and are considered to be clinically important
A. Wra and Wrb
b. anti - Yta and Ytb
c. Anti-Xga
d. Sc2
Antibodies: Both anti-Yta and Anti-Ytb are IgG antibodies reactive in IAT and are considered to be clinically important
Yt antigens have been located on ____________
a. anion exchnge molecule
b. acetylcholinesterase
c. short arm chromosome X
d. chromosome 1 at 1p34
Yt antigens have been located on erythrocyte acetylcholinesterase,, which is an enzyme involved in NEUROTRANSMISSION
CARRIED PROTEIN WITH CELL ADHESION THAT HAS BEEN DEMONSTRATED TO HAVE A HOMOLOGY WITH cd 99 MOLECULE
A. diego
b. cartwright
c. XG
d, Scianna
ISBT 012 XG
Antigen: Xga
✓ Gene that encodes for the Xg allele is located on the short arm of the X chromosome
✓ Xga antigen is carried by a protein with cell adhesion properties that has been demonstrated to have homology with the CD 99 molecule
what is the protein product of Scianna
a. erythrocyte acethylcholinesterase
b. anion exchange molecule
c. erythroid membraneassociated protein
d. Xg a antigen
ISBT 013 SCIANNA
Antigens: Sc1, Sc2 and Sc3 antigens
✓ The very rare Sc:–1,–2,–3 phenotype is the Scianna null type.
✓ The SC gene is located on chromosome 1 at 1p34. The product of the gene is a protein called erythroid membraneassociated protein (ERMAP), which is an RBC adhesion protein.
which of the following bgs is located at chromosome 1 at 1p34
A. diego
b. cartwright
c. XG
d, Scianna
ISBT 013 SCIANNA
Antigens: Sc1, Sc2 and Sc3 antigens
✓ The very rare Sc:–1,–2,–3 phenotype is the Scianna null type.
✓ The SC gene is located on chromosome 1 at 1p34. The product of the gene is a protein called erythroid membrane associated protein (ERMAP), which is an RBC adhesion protein.
which BGS does antigen Joseph belongs
a. scianna
b. cromer
c. dombrock
d. colton
ISBT 014 DOMBROCK
Antigens: Doa , Dob , Gregory (Gya) , Holley (Hy) , Joseph (Joa)
Anti-Doa and Anti-Dob are described as IgG, red cell-stimulated antibodies that react primarilty in IAT with _______________ or enzyme enhancement - not associated with HDN, but reported to cause delayed transfusion reactions
a. erythroid membrane associated protein (ERMAP
b. polyethylene glycol (PEG)
c. erythrocyte acetylcholinesterase\
d. aota
ISBT 014 DOMBROCK
Antigens: Doa , Dob , Gregory (Gya) , Holley (Hy) , Joseph (Joa)
Antibodies:
✓ Anti-Doa and Anti-Dob are described as IgG, red cell-stimulated antibodies that react primarilty in IAT with polyethylene glycol (PEG) or enzyme enhancement - not associated with HDN, but reported to cause delayed transfusion reactions
what bgs is located on the transport protein known as channel forming integral protein (CHIP)
a. dombrock
b. colton
c. chido/rodgers
d. gerbrich
ISBT 015 COLTON
Antigen: Coa , Cob , Co3(formerly Coab
)
✓ CO antigens have been located on the transport protein known as channel forming integral protein (CHIP) , which FORMS PRIMARY RBC WATER CHANNEL and is RESPONSIBLE FOR WATER PERMEABILITY
which of the bgs is responsible for water permeability
a. dombrock
b. colton
c. chido/rodgers
d. gerbrich
ISBT 015 COLTON
Antigen: Coa , Cob , Co3(formerly Coab
)
✓ CO antigens have been located on the transport protein known as channel forming integral protein (CHIP) , which FORMS PRIMARY RBC WATER CHANNEL and is RESPONSIBLE FOR WATER PERMEABILITY
which of the following colton antibodies is associated with severe HDN
a. anti- Coa
b. anti- Cob
c. anti - Co3
✓ Both anti-Coa and Anti-Cob are IgG, red cell stimulated and reactive in IAT, and associated with DHTR
✓ Anti-Co3 is characterized as IgG, red cell stimulated, complement binding, and reacting in the IAT, and associated with severe HDN
which of the following colton antibodies is associated with delayed hemolytic anemia
a. anti- Coa
b. anti- Cob
c. anti - Co3
✓ Both anti-Coa and Anti-Cob are IgG, red cell stimulated and reactive in IAT, and associated with DHTR
✓ Anti-Co3 is characterized as IgG, red cell stimulated, complement binding, and reacting in the IAT, and associated with severe HDN
associated with HTA system
a. dombrock
b. colton
c. chido/rodgers
d. gerbrich
ISBT 017 CHIDO/RODGERS
Antigens: 6 Ch antigens, 2 Rodgers antigen, WH antigen
✓ Postulated that CH/RG antigens were associated with HLA system
✓ Alleles for RG and CH have been located on two closely linked genes known as C4A and C4B on ch#6
which of the BGS has chracteristics of nebolous
a. dombrock
b. colton
c. chido/rodgers
d. gerbrich
ISBT 017 CHIDO/RODGERS
Antigens: 6 Ch antigens, 2 Rodgers antigen, WH antigen
✓ Postulated that CH/RG antigens were associated with HLA system
✓ Alleles for RG and CH have been located on two closely linked genes known as C4A and C4B on ch#6
✓ Serologically, they were both characterized as NEBOLOUS because antigen strength on different samples of RBCs was variable
Ge antigens are inherited oN _________ and are expressed on glycophorins C and/or Glycophorin D
a. Chromosome 1
b. AE1
c. chromosome x
d. chromosome 2
Ge antigens are inherited on chromosome 2 and are expressed on glycophorins C and/or Glycophorin D
