transfusion reaction II Flashcards
blood component commonly associated with transfusion related sepsis?
a. leukopoor
b. washed rbc
c. platelet concentrate
d. platelet pheresis
platelet concentrate
Platelets have been the most frequent source of septic transfusion reactions because room temperature storage promotes bacterial growth.
greatest number of deaths due to blood product contamination
a. Y. enterocolitica
b. Pseudomonas putida
c. S. aureus
d. S. epidermidis
Staphylococcus aureus
accounts for the greatest number of deaths due to blood product contamination reported to the FDA from FY2011 to 2015, all of which were platelet products (Harmening, 7th edition)
are the most common bacterial contaminants of blood
a. Y. enterocolitica
b. Pseudomonas putida
c. S. aureus
d. S. epidermidis
Staphylococcus epidermidis or Staphylococcus aureus are the most
common bacterial contaminants of blood
Most frequently recovered from donated blood and contamination of platelet
a. B. cerues
b. Pseudomonas putida
c. S. aureus
d. S. epidermidis
Bacillus cerues,
Staphylococcus epidermidis
Most frequently recovered from donated blood and contamination of platelet
Common isolate of human skin, WAS the most common bacterial contaminants in RBC
a. B. cerues
b. Pseudomonas putida
c. Propionebacterium acnes
d. S. epidermidis
Propionebacterium acnes
- common isolate of HUMAN SKIN
- WAS the most common bacterial contaminants in rbcs
Most common cause of death by bacterial contaminated blood components
a. Y. enterocolitica
b. Pseudomonas putida
c. S. aureus
d. S. epidermidis
Yersinia enterocolitica
According to CDC, it is the Most common cause of death by bacterial contaminated blood components
Most common isolate found in RBC units
what delayed immune transfusion reaction due to an immunologic attack by viable donor lymphocytes
(T cells) contained in the transfused blood component against the transfusion recipient.
a. dhtr
b. ta-gvhd
c. ptp
d. iron overload
TA-GVHD Transfusion associated-graft versus host disease
Cause: delayed immune transfusion reaction due to an immunologic attack by viable donor lymphocytes
(T cells) contained in the transfused blood component against the transfusion recipient.
-Recipient who are immunocompromised or with immunodeficiencies, with cancer, or infants are at risk
what DTR has decrease in haptoglobin
a. dhtr
b. ta-gvhd
c. ptp
d. iron overload
DHTR
Cause: Incompatible blood transfusion especially KIDD BGS (most common)
Signs and symptoms: Fever, decreased haptoglobin level, mild jaundice, flu-like symptoms, pallor
what DTR has a maculopapular skin rash, scleroderma like, sicca syndrome and diarrhea in stool
a. dhtr
b. ta-gvhd
c. ptp
d. iron overload
TA-GVHD Transfusion associated-graft versus host disease
Signs and Symptoms: Fever, maculopapular skin rash, scleroderma-like, sicca syndrome, interstitial pneumonitis, pancytopenia, abnormal liver function (elevated liver function test such as enzymes), diarrhea with bloody stool
what condition will develop in HLA antigen difference between donor and recipient
a. dhtr
b. ta-gvhd
c. ptp
d. iron overload
Three conditions must exist for TA-GVHD to develop in a recipient:
- HLA antigen difference between donor and recipient
- presence of donor immunocompetent cells in the blood component
- recipient incapable of rejecting the donor immunocompetent cells
what blood component should be transfused in TA-GVHD
a. leukopoor
b. washed rbc
c. platelet con
d. irradiated blood products
TA-GVHS
prevention and treatment
- usage of irradiated blood products
- usage of immunosuppressive medications
- Hematopoietic stem cell transplantation
what DTR is caused by anti - HPA! antibodies
a. dhtr
b. ta-gvhd
c. ptp
d. iron overload
Post transfusion purpura
Cause: Anti-platelet antibodies / anti-HPA1(human platelet antigen1) antibodies
delayed, nonimmune complication of transfusion, presenting with multiorgan (i.e., liver, heart, endocrine organs) damage
a. dhtr
b. ta-gvhd
c. ptp
d. iron overload
iron overload / transfusion induced/ hemosiderosis/ hemochromatosis
causes : delayed, nonimmune complication of transfusion, presenting with multiorgan (i.e., liver, heart, endocrine organs) damage
