1.14 ECM II - Matrix Proteins Flashcards Preview

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Flashcards in 1.14 ECM II - Matrix Proteins Deck (13):
0

Name the two structural proteins in the ECM

Collagen
Elastin

1

Name the 2 Adhesion proteins in the ECM

Fibronectin
Laminin

2

Collagen is synthesized and secreted by

Fibroblasts

3

Describe the unusual primary structure of the alpha-collagen peptide

Few amino acids that are repetitive
1. Glycine
2. Proline
3. Hydroxyproline and Hydroxylysine

4

T or F, All collagen types are constructed from 3 left handed helical peptide chains

True

5

Which type of collagen accounts for 90% of the body's collagen

Type I

6

4 steps of collagen post translational modifications

Hydroxylation of Proline and Lysine residues
Glycosylation of Hydroxyl-lysine
Cleavage of N and C terminal propeptides (topocollagen)
Cross-linking of lysine residues to form fiber

7

Which step in collagen modification requires Ascorbate or Vitamin C?

Hydroxylation of proline and lysine residues

8

What enzyme helps cross-link lysine residues when forming the fiber

Lysyl Oxidase

9

What are the three difference of non fibrillar collagen and fibrillar collagen

1. lack glycine in primary structure for tight collagen helix
2. not cleaved after secretion so they retain propeptides
3. Do not aggregate with one another to form fibrils

10

What is the 3 step process of collagen degradation

1. Enzyme binding
2. Unwinding of triple helix
3. Cleavage of collagen peptides

11

Two enzymes available for Collage degradation

Matrix Metalloproteinases
Cathepsins

12

Which disorder is characterized by a decrease in Type I Collagen synthesis and are manifested by long bone fractures prior to maturity

Osteogenesis Imperfecta I