2.11 Methyl transport Flashcards Preview

Metabolism > 2.11 Methyl transport > Flashcards

Flashcards in 2.11 Methyl transport Deck (29):
0

The three things that make up the structure of Folic Acid

Pteridine ring
p-aminobenzoate (PABA)
Glutamate

1

A lack of what vitamin is the most common vitamin deficiency in the world

Folic Acid

2

Outline briefly how Folic Acid is turned into Tetrahydrofolate

Folic Acid --> Dihydrofolate
Dihydrofolate --> Tetrahydrofolate

3

What enzyme catalyzes the two reactions that takes folic acid to tetrahydrofolate

Dihydrofolate Reductase

4

How does Tetrahydrofolate differ from Folic Acid

It contains two extra hydrogens on the amino groups

5

What is the function Methotrexate?

It is a structural analogue of dihydrofolate
Is used as an inhibitor of Dihydrofolate Reductase

6

What is the role of Tetrahydrofolate and S-adenosyl methionine in the cell?

It carries methyl groups

7

How does Tetrahydrofolate differ from SAM in its function?

SAM is main carrier of Methyl groups
Tetrahydrofolate carries oxidized version of Methyl like Methylene

8

Name the five versions of one carbon groups that Tetrahydrofolate carries?

Methyl (CH3)
Methylene (CH2)
Formyl (CHO)
Formimino (CHNH)
Methenyl (CH=)

9

What conversion is the major source of a carbon to be moved?

Serine to Glycine

10

T or F, Different forms of tetrahydrofolate are interconvertible

True

11

How is SAM formed?

Methionine + ATP --> SAM

12

What enzyme catalyzes the conversion of Methionine to SAM?

Methionine Adenosyl Transferase

13

How is Methionine formed

Methyl group + Homocysteine = Methionine

14

What enzyme catalyzes reaction that makes methionine?

Methionine Synthase

15

What is the coenzyme with Methionine Synthase?

Vitamin B12

16

What is the rate limiting step in the activated methyl cycle

Methylene FH4 --> Methyl FH4

17

What enzyme catalyzes the rate-limiting step of the activated methyl cycle

Methylene Tetrahydrofolate Reductase

18

What is the Transulfuration pathway

When homocysteine is converted to cysteine

19

Alanine is made from an amino acid and what other molecule?

Pyruvate

20

Oxaloacetate + Amino acid = ?

Aspartate

21

Glutamate is formed from an amino acid and what other molecule?

Alpha-ketoglutarate

22

What enzyme catalyzes reaction of glutamate to glutamine

Glutamine synthetase

23

Serine + Homocysteine --> ?

Cysteine

24

Formation of cysteine from homocysteine is dependent on what?

Dependent on Methionine, an essential AA

25

Tyrosine is formed from what AA?

Phenylalanine

26

WHat enzyme catalyzes the formation of Tyrosine from another AA

Phenylalanine hydroxylase

27

What is the underlying issue behind the PKU disorder

Inability to convert Phenylalanine to Tyrosine. Phenylalanine accumulates and inhibits brain development

28

Reaction of Phenylalanine to Tyrosine includes what two things during the reaction?

O2 and coenzyme Tetrahydrobiopterin