1.3 Cell signalling Flashcards Preview

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Flashcards in 1.3 Cell signalling Deck (12):
0

Name the 4 approaches to cell signaling

1. Endocrine signaling
2. Paracrine signaling
3. Autocrine signaling
4. Plasma membrane-attached proteins

1

Define endocrine signaling

Hormone secretion into blood by endocrine gland

2

Define Paracrine signaling

Secretory cell signaling to adjacent target cell

3

What type of signaling has target sites on the same cell?

Autocrine signaling

4

What is bound to the inactivated G-protein subunit before it binds to the receptor

GDP

5

An activated receptor causes conformation change in G-protein triggering what action?

The dissociation of GDP

6

What finally activates the G-protein after it has been bound to the receptor

G-protein binds GTP and becomes activated

7

What enzyme catalyzes the conversion of ATP into cAMP

Adenylate cyclase

8

What causes the dissociation of G-protein from Adenylate Cyclase

Hydrolysis of GTP to GDP

9

cAMP activates what?

Protein Kinase A

10

What are the two actions of Protein Kinase A

1. Phosphorylates Serine & Threonine residues in many targets to alter their activity
2. Stimulates expression of CREB

11

What two things end transduction

1. Dissociation of Ligand
2. Phosphorylation of C-terminal tail of receptor and subsequent binding of B-arrestin