2.6 Fatty Acid Biosynthesis Flashcards Preview

Metabolism > 2.6 Fatty Acid Biosynthesis > Flashcards

Flashcards in 2.6 Fatty Acid Biosynthesis Deck (25):
0

Where does Fatty Acid Biosynthesis occur?

Cytosol of Liver

1

What is the main substrate for synthesis?

Acetyl CoA

2

How does Acetyl CoA move across the mitochondrial membrane?

Acetyl CoA + Oxaloacetate = Citrate
Citrate can be moved across the membrane

3

What enzyme catalyzes reaction of Acetyl CoA and Oxaloacetate to Citrate

Citrate Synthase

4

What enzyme catalyzes the reaction that occurs to take Citrate to Acetyl CoA and Oxaloacetate

Citrate Lyase

5

What 3 things regulate FA biosynthesis

High Citrate
High ATP
High Acetyl CoA

6

WHat enzyme catalyzes reaction of Acetyl CoA to Malonyl CoA

Acetyl CoA Carboxylase

7

What is the coenzyme in the reaction of acetyl CoA to Malonyl COA

Biotin

8

What is the rate limiting step of FA biosynthesis

Acetyl CoA --> Malonyl CoA

9

Carboxylation reactions require what three things?

Biotin
ATP
CO2

10

How is Acetyl CoA Carboxylase activated?

PP2A dephosphorylates Acetyl CoA Carboxylase

11

What three things regulate Acetyl CoA Carboxylase

High levels of AMP deactivate
High levels of Insulin
Low levels of Glucagon and Epinephrine

12

T or F, High levels of Citrate promote FA biosynthesis

True

13

Low levels of Malate and Epinephrine do what to Acetyl CoA Carboxylase?

They Activate the enzyme and therefore promote FA synthesis.

14

What are the normal substrates to form a Palmitate molecule

8 Acetyl CoA, 14 NADPH, 7 ATP, 14 H+

15

What four reactions are involved in Fatty Acid synthesis

Condensation --> Reduction --> Dehydration --> Reduction

16

In what two pathways does the NADPH come from that helps FA Synthesis

Pentose Phosphate Pathway
Malate to Pyruvate

17

What do you lose when Acetyl CoA is added to Malonyl CoA

CO2 (condensation)

18

When the four carbon unit is removed from ACP and moved to CE acp, what is needed?

2 NADPH

19

Where does Fatty Acid ELongation occur?

on the cytoplasmic face of ER

20

What enzyme is involved in Fatty Acid Elongation

Fatty Acid Elongase

21

Fatty Acid Desaturation takes place where and by what enzyme?

In the ER
Fatty Acid Desaturase

22

What are the essential precursors of TAGs

G3P
DHP (Dihydroxyacetone Phosphate)
FFA
Phosphatidate

23

Where are TAGs synthesized

Liver and Adipose tissue

24

Why are TAGs only made in adipose in the Fed state when glucose available

Because adipose tissue does not have the enzyme glycerol kinase and needs a rich supply of glucose available