Carbohydrate Metabolism 2

Question 1

Location of TCA Cycle

Answer 1

Mitochondrial Matrix

Question 2

Pyruvate Dehydrogenase

Answer 2

Question 3

Importance of Pyruvate Dehydrogenase Reaction

Answer 3

Commits pyruvate to TCA cycle and is the Rate-Limiting Step

Question 4

Is the Pyruvate Dehydrogenase reaction reversible

Answer 4

PDH Reaction is irreversible

Question 5

Regulation of PDH Reaction

Answer 5

Allosteric
Covalent
Hormonal (Insulin activates)

Question 6

Enzyme complexes in Pyruvate Dehydrogenase

Answer 6

3 Enzyme complexes

Question 7

Coenzymes of Pyruvate Dehydrogenase

Answer 7

Thiamine pyrophosphate (Just remember Thiamine)
Lipoamide
CoA
FAD+
NAD+

Question 8

Mechanism of Pyruvate Dehydrogenase

Answer 8

Decarboxylation of Pyruvate
Formation of Acetyl CoA
Regeneration of Oxidised Lipoamide

Question 9

Covalent Regulation of PDH

Answer 9

Question 10

Citrate Synthase

Answer 10

Question 11

Reaction of Citrate Synthase

Answer 11

Question 12

Aconitase

Answer 12

Question 13

Reaction of Aconitase

Answer 13

Question 14

Isocitrate Dehydrogenase

Answer 14

Question 15

Reaction of Isocitrate DH

Answer 15

Question 16

Alpha Ketoglutarate Dehydrogenase

Answer 16

Question 17

Reaction of Alpha Ketoglutarate Dehydrogenase

Answer 17

Question 18

Succinyl CoA synthase

Answer 18

Question 19

Reaction of Succinyl CoA synthase

Answer 19

Question 20

Succinate Dehydrogenase

Answer 20

Question 21

Reaction of Succinate Dehydrogenase

Answer 21

Question 22

Fumarase

Answer 22

Question 23

Reaction of Fumarase

Answer 23

Question 24

Malate Dehydrogenase

Answer 24

Question 25

Reaction of Malate Dehydrogenase

Answer 25

Question 26

Products made from each molecule of Acetyl CoA Oxidised

Answer 26

3 NADH + 1 FADH2 + 2 CO2 + 1 GTP

Question 27

Medical Problems Associated with TCA Cycle

Answer 27

NONE!