ENERGY METABOLISM III AND IV Flashcards
functions as a rotary motor to form ATP
imbedded in the inner mitochondrial membrane
consists of Fo subcomplex, Gamma subunit, and F1 subcomplex
ATP synthase
disk of c protein subunits
Fo subcomplex
attached to Fo and F1 complexes
gamma subunitm
made up of 3 alpha and 3 beta subunits
F1 subcomplex
in ATP synthase
_____ ATPs are generated per revolution of beta subunits
3 ATPs
availability of ADP and and reduced substrate
state 1
availability of substrate only
state 2
the capacity of the respiratory chain itself when all substrates and components are present in saturating amounts
state 3
availability of ADP only (e.g. cells in the resting state)
state 4
availability of oxygen only
state 5
cell approaches during exercise to state ______ or ______
state 3 or 5
P-O ratio for NADH
2.5
P-O ratio for FADH2
1.5
function: e-transport inhibitor for Iron-sulfur center to CoQ
Complex 1
barbiturates (rotenone)
electron transport inhibitor
complex 1
amytal
electron transport inhibitor
because of structural similarity between malonic acid and succinic acid
complex 2
malonate
electron transport inhibitor
complex III
antimycin A and dimercaprol
electron transport inhibitor
complex IV
cyanide, hydrogen sulfide, carbon monoxide, azide