NUCLEOTIDE METABOLISM Flashcards
nucleotide synthesis
you make bases
de novo pathways
pathways in nucleotide synthesis
recycle the free bases and nucleosides from nucleic acid breakdown
salvage pathways
active form of ribose 5 phosphate
important in both de novo and salvage pathways
phosphoribosyl pyrophosphate
base is made and is attached to the ribose the whole process
needs PRPP
Glycine
IMP
purine
base is made WITHOUT ribose.
base is only attached to the ribose once base is completely formed needs PRPP
aspartate
OMP
pyrimidine
synthesis of inosine monophosphate starts from ribose 5 phosphate which is derived from the _______
HMP shunt
synthesis of inosine monophosphate requires _______ steps overall
11 steps
step 1 is the activation of ________
enzyme is ___________
ribose 5 phosphate
ribose 5 phosphate pyrophosphokinase
in synthesis of inosine monophosphate step 2 is the __________
the enzyme is ____
rate limiting stem
PRPP glutamylamidotransferase
in step 3 of synthesis of inosine monophosphate
there is acquisition of __,__, and ____
C4,C5,N7
step 4 of synthesis of inosine monophosphate is the acquisition of _____
this is not _______ driven
C8
ATP
in step 5 of inosine monophosphate biosynthesis there is acquisition of ______
the coenzyme is ______ and ________
C8
Glutamine and ATP
in step 6 of the synthesis of inosine monophosphate is the closure of the _______ ring
imidazole
in step 8 of IMP synthesis
the coenzyme is ____ and ____
aspartate and ATP
Step 11 of IMP synthesis
enzyme that closes the 2nd ring: ___________
IMP cyclohydrolase
amino acid donor for AMP
aspartate
amino acid donor for GMP
glutamine
IMP will use _________ to produce AMP
GTP