SPECIAL TISSUES II Flashcards

1
Q

alterations of the levels of various factors result in an increase of osteoclastic activity over osteoblastic activity

loss of estrogen is critical

A

osteoporosis

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2
Q

strongly associated with mutations of fibroblast growth factor receptor 1

defective genes are _________ and ________

A

pfeiffer syndrome
FGFR1; FGFR2

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3
Q

autosomal dominant
50% due to spontaneous mutation
due to mutation of FGFR2 at chromosome 10

A

bone-crouzon syndrome

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4
Q

bone-crouzon dermoskeletal syndrome

due to mutation of _________

A

FGFR-3

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5
Q

Cartilage

principal protein is type __ collagen

_____ is the major proteoglycan

A

cartilage

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6
Q
A
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