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Flashcards in 17. Heme Deck (72)
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1

What coagulation factor is deficient in hemophilia A?

8

2

What coagulation factor is deficient in hemophilia B?

9

3

What is the clinical consequence of a deficiency in either protein C or protein S?

hypercoagulable

4

What is the treatment for overdose of heparin?

protamine sulfate

5

What is the treatment for heparin-induced thrombocytopenia?

- stop heparin
- start different anticoagulant

6

What allows RBCs to change shape as they pass through vessels?

spectrin

7

What name is given to immature erythrocytes in circulation?

reticulocytes

8

What pathologic form of RBC would you see in each of the following diseases?
- lead poisoning

basophilic stippling

9

What pathologic form of RBC would you see in each of the following diseases?
- G6PD deficiency

Heinz bodies --> bite cells

10

What pathologic form of RBC would you see in each of the following diseases?
- DIC

schistocytes

11

What pathologic form of RBC would you see in each of the following diseases?
- abetalipoproteinemia

acanthocyte (spur cell)

12

What pathologic form of RBC would you see in each of the following diseases?
- asplenia

Howell-Jolly bodies
Target cells

13

Where does fetal erythropoiesis take place?

Yolk sac --> liver --> spleen --> BM

14

In which adult bones does erythropoiesis take place?

axial skeleton: vertebrae, ribs, pelvis

15

What are some of the diff. causes of polycythemia? (4)

- ectopic EPO (pheo, RCC, HCC, hemangioblastoma)
- chronic hypoxia
- polycythemia vera
- trisomy 21

16

What are the hematologic and non-hematologic findings in a patient with lead poisoning?

hematologic: microcytic anemia, basophilic stippling
non-heme: encephalopathy, memory loss, HA, foot/wrist drop, lead lines on gingivae, abdominal colic, renal failure

17

What test can be used to diagnose beta-thalassemia minor?

Hb electrophoresis (will see increased HbA2)

18

What should you r/o in a man over 50 with new-onset iron deficiency anemia?

colon cancer

19

A patient is diagnosed with a macrocytic, megaloblastic anemia. What is the danger of giving folate alone?

uncorrected B12 def --> peripheral neuropathy

20

What is the cause of anemia?
- microcytic anemia + swallowing difficulty + glossitis

Plummer Vinson syndrome

21

What is the cause of anemia?
- microcytic anemia, >3.5% HbA2

beta-thal minor

22

What is the cause of anemia?
- megaloblastic anemia not correctable by B12 or folate

orotic aciduria

23

What is the cause of anemia?
- megaloblastic anemia along with peripheral neuropathy

b12 deficiency

24

What is the cause of anemia?
- microcytic anemia + basophilic stippling

lead poisoning

25

What is the cause of anemia?
- microcytic anemia reversible with B6

sideroblastic anemia
(note: B6 is cofactor for delta-ALA synthase)

26

What is the cause of anemia?
- HIV-positive patient with macrocytic anemia

zidovudine (HIV drug)

27

What is the cause of anemia?
- normocytic anemia and elevated creatinine

chronic kidney disease

28

A child anemic since birth has now been cured with splenectomy. What is the disease?

hereditary spherocytosis

29

What findings are associated with hereditary spherocytosis?

anemia, jaundice (b/c extravascular), pigmented gall stones, splenomegaly
- (+) osmotic fragility test
- (-) Coombs

30

What is the difference b/w hemoglobin S defect and hemoglobin C?

HbS (sickle cell) glu --> valine
HbC: glu --> lysine