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Flashcards in 8. Immuno Deck (64)
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1

To which lymph nodes do the sigmoid colon and the rectum drain?

sigmoid colon: inf mesenteric

upper rectum: inf mesenteric

lower (to pectinate line): int iliac

lower (below pec line): sup inguinal

2

In what parts of the lymph nodes would B cells and T cells be located?

B cells: follicles (of the cortex)
T cells: paracortex

3

Where would you find Peyer's patches?

ileum (in lamina propria + submucosa)

4

What molecules are expressed on the surface of antigen-presenting dendritic cells?

- MHC class 1, 2
- B7 protein
- CD40

5

What 3 cell types are known for presenting antigens to CD4+ T cells?

- dendritic cells
- macrophages
- B cells

6

What characteristic finding would you see on electron microscopy of a dendritic cell in a pt with Langerhans cell histiocytosis?

Birbeck granules (tennis racket)

7

Which cytokines are produced by Th1 cells? by Th2 cells?

Th1 = IL-2, IFN-gamma
Th2= IL-4, IL-5, IL-10

8

Which cytokines inhibit Th1 cells? Which inhibit Th2 cells?

Th1 --> IL-10
Th2 --> IFN-gamma

9

How do cytotoxic T cells kill virus-infected cells and neoplastic cells?

1. granzyme B + perforin
2. Fas-ligand on T-cell binds to Fas-receptor on target cell --> induce apoptosis

10

Which surface markers are found on B-cells?

CD19, 20, 21
IgM, IgD
MHC class I, 2
B7 protein
CD40

11

What immunoglobulin is associated with allergies b/c it is bound by mast cells and basophils and causes them to degranulate and release their histamine?

IgE

12

What immunoglobulin comprises 70-75% of the total immunoglobulin pool?

IgG

13

What immunoglobulin is present in large quantities on the surface of many B cells?

IgD, IgM

14

What immunoglobulin crosses the placenta and additionally confers immunity to neonates in the first few months of life?

IgG

15

What immunoglobulin can occur as a dimer?

IgA (secretory)

16

What immunoglobulin is largely confined to the intravascular pool and is the predominant early antibody frequently seen in the immune response to infectious organisms with complex antigens?

IgM

17

What immunoglobulin is distributed evenly b/w the intravascular and extravascular pools?

IgG

18

What immunoglobulin is the predominant immunoglobulin in mucoserous secretions such as saliva, colostrum, milk, tracheobronchial secretions, and GU secretions?

IgA

19

What immunoglobulin can be a pentamer?

IgM

20

What initiates recombination of V(D)J sequences?

RAG-1, RAG-2
--> recombination activating genes

21

Which viral vaccines are potentially dangerous to pts with an egg allergy? (2)

- influenza
- yellow fever

22

What autoimmune disease is associated with anti-dsDNA antibodies?

SLE

23

What stain is used to identify amyloid microscopically, and how is its appearance described?

congo red stain
- apple green birefringence under polarized light

24

Which type of hypersensitivity is responsible for post-strep GN?

3

25

Which type of hypersensitivity is responsible for asthma?

1

26

Which type of hypersensitivity is responsible for rheumatic fever?

2

27

Which type of hypersensitivity is responsible for tuberculosis skin test (PPD)?

4

28

Which type of hypersensitivity is responsible for allergies, anaphylaxis, and hay fever?

1

29

Which type of hypersensitivity is responsible for polyarteritis nodosa (PAN)?

3

30

Which type of hypersensitivity is responsible for serum sickness?

3