[17] Pathology of Ischemic Heart Diseases Flashcards Preview

[OS 213] CVS Module > [17] Pathology of Ischemic Heart Diseases > Flashcards

Flashcards in [17] Pathology of Ischemic Heart Diseases Deck (10):
1

Common Sites of Atherosclerosis

Aorta

Coronary Arteries

Internal Carotid Arteries

Circle of Willis

2

Plaque Components (6)

Smooth Muscle Cells

Connective Tissue

Matrix Macrophages

Basophils

T Lymphocytes

Lipid: Extracellular and Intracellular

 

SCM:BLT

3

Mechanisms of Plaque Formation

1. LDL move freely in and out of intima

2. Small proportion of LDL undergoes minor modification and oxidative change

3. Modified LDL acts as an inflammatory stimulus and induces endothelial cells to produce adhesion molecule expression

4. Adhesion of circulating monocytes to intact endothelial cells and migration

5. Modified LDL taken up by macrophage scavengers and become foam cells

6. Macrophages are potent sources of smooth muscle cell growth factors

4

Define: 

Type II Atherosclerotic Lesion

Fatty Streak

5

Define:

 

Type III Atherosclerotic Lesion

Lipid Foam Cell

6

Define:

 

Type IV Atherosclerotic Lesion

W/ Lipid Core

W/ Fibrous Cap

7

Define: 

 

Type V Atheroscleroic Lesions 
Va

Vb
Vc

Advanced, raised lesion

 

Va: Fibroatheroma

Vb: Calcified Lesion

Vc: Fibrotic Lesion

8

Define:

Type VI Atherosclerotic Lesion

Complicated

Type IV or V with hemorrhages

9

Define:

 

Endothelial Erosion

Areas of endothelial loss and intimal erosion over a plaque

 

10