[33] Pharma III Anti-Arrhthmics and Angina Flashcards Preview

[OS 213] CVS Module > [33] Pharma III Anti-Arrhthmics and Angina > Flashcards

Flashcards in [33] Pharma III Anti-Arrhthmics and Angina Deck (45):
1

What route is Nitroglycerin taken in?

Sublingual Route

2

Drug of Choice for Vasospastic Diseases

Nitrates and CCBs

3

Oral Bioavailability of Nitroglycerin

10-20%

4

Duration of Effect of Nitroglycerin

15-30 Minutes

5

Main problem with Nitrates

Tolerance

6

What interval should you take Nitroglycerin in?

8-16-24 Hour

7

At low concentrations of nitrates what responds?

Veins

8

At slightly higher than the low concentration of nitrates what responds?

Arteries

9

Mechanism of Action of Nitrates

Decreased Preload
Increased Venous Compliance

that HAS A SIDE EFFECT of

Dilating Coronary Arteries

(The first two points are the main way it works)

10

#1 Side Effect of Nitrates

Headache

11

Drug for Supraventricular Tachycardia

Diltiazem
Verapamil

12

#1 Side Effect of Old Generation CCBs

Give an example

Reflex Tachycardia

Nifedipine

13

Contraindications for Short-Acting CCBs

Unstable Angina

14

Why would you give someone very tiny physiologic amounts of Beta Blockers?

Allow transcription to upregulate receptors to allow adrenergic stimulation again

15

Latest Beta Blocking Drug

Nebivolol

16

Mechanism of Action of Ivabradine

If Inhibitor

17

What Phase of Contraction is equivalent to the QRS complex?

Phase 0

18

Do fast or slow Potassium channels open first?

Slow followed by a rapid fast Potassium extrusion

19

Can SA and AV nodes be affected by Na Channel Blockers?

No, because they use calcium channels

20

How do you delay Phase 4 Depolarization?

Potassium Channel Blockers

21

[Vaughan-Williams Classification]

Class I

Na Channel Blockers

22

[Vaughan-Williams Classification]

Class II

Beta-Blockers

23

[Vaughan-Williams Classification]

Class III

Potassium Channel Blockers

24

[Vaughan-Williams Classification]

Class IV

Calcium Channel Blockers

25

[Vaughan-Williams Classification]

Function: Class IA

Prolongs Action Potential Duration

26

[Vaughan-Williams Classification]

Function: Class IB

Shortens Action Potential Duration

27

[Vaughan-Williams Classification]

Function: Class IC

Minimal Action Potential Effects

28

Examples of Class IA Drugs

Quinidine
Procainamide
Disopyramide

29

Examples of Class IB Drugs

Mexiletine
Lidocaine
Tocainide

30

Examples of Class IC Drugs

Flecainide
Moricizine
Propafenone

31

Sodium Channel Blockers Block Which Phase?

Phase 0

32

[Potency for Sodium Channel Blockade]

Class IA
Class IB
Class IC

A: Moderate

B: Minimal

C: Marked

C > A > B

33

Amiodarone Blocks Which Channels

Calcium
Beta
Sodium

34

Effect of Adrenergic Receptor Agonists on Potassium Channels

Stimulation of opening of K Channels causing Hyperpolarization

35

What do you give to patients with Atrial Flutter or Fibrillation

Class 1A Sodium Channel Blockers

36

What drug toxicity can cause Torsades de Pointes

Class 1A Sodium Channel Blockers

37

What drug toxicity causes Cinchonism?

Quinidine

38

Effect on Quinidine on Digoxin

Raises the levels

39

What drug can cause REVERSIBLE Lupus-Like Syndrome

Procainamide

(Hydralazine also causes SLE Symptoms but I don't know if it's reversible)

40

Major Metabolite of Procainamide

NAPA
N-Acetylprocainamide

41

Examples of Class III Drugs

Amiodarone
Bretylium
Sotalol
Dofetilide
Ibutilide

42

Classes of Drugs that Prolong Action Potential?

Class 1A
Class III

43

Pulmonary Fibrosis can result as a toxicity of which drug?

Amiodarone

44

Mechanism of Action of Adenosine

Opens K Channels
Inhibits Ca Channels

45

Half Life Adenosine

10 Seconds