[23] Pharmacology I Flashcards Preview

[OS 213] CVS Module > [23] Pharmacology I > Flashcards

Flashcards in [23] Pharmacology I Deck (22):
1

When should you administer the first dose of Alpha-1 Blockers? Is it a large or small dose?

Small dose administration at bedtime

2

Function: Guanethidine

Inhibit Ca2+ dependent release of NE

3

Function: Reserpine

Blocks vesicles to take up and store biogenic amines

4

Examples of Alpha-2 Agonist Specific Receptors

Clonidine
Methyldopa

5

Onset of Action of Furosemide

Oral
IV

O: 2 hours
IV: 20 minutes

6

Effects of Furosemide Toxicity

Ototoxicity
Hypokalemia
Dehydration
Allergy
Nephritis
Gout

"OH DANG"

7

Drugs that cause "First-Dose" Phenomenon

Alpha-1 Selective Blockers

8

For patients with BPH and HPN what drug should you give?

Alpha-1 Selective Blockers

9

Hexamethonium toxicity causes?

1. Excessive orthostatic hypotension
2. Sexual dysfunction
3. Constipation
4. Urinary retention
5. Precipitation of Glaucoma
6. Blurry Vision
7. Dry Mouth

10

Hexamethonium Mechanism of Action

Blocks nicotinic cholinoceptors on both sympathetic and parasympathetic ganglia

11

This drug causes Lupus-like syndrome in cases of toxicity

Hydralazine

12

Hydralazine's Mechanism of Action

Causes Nitric Oxide release and subsequent vasodilation

13

This drug causes hirsutism in cases of toxicity

Minoxidil

14

This drug is known to cause reflex tachycardia

Minoxidil

15

This drug is a potassium sparing diuretic

Spironolactone

16

Mechanism of Action of Spironolactone

Aldosterone Antagonist

17

Pharmacokinetics of Digoxin:

1. % Bioavailability
2. % Protein Bound
3. Half Life
4. Does it undergo enterohepatic circulation?
5. What fraction is excreted unchanged in the kidney?
6. Does it have a narrow or wide therapeutic index

1. 75% F
2. 20-40% Protein Bound
3. T1/2 = 40 Hours
4. Yes, so long T1/2
5. 2/3 Excreted Unchanged
6. Narrow Therapeutic Index

18

Major Limitation of Dopamine

Tolerance or Desensitization

19

The drug choice for patients with congestive heart failure, hypotension and oliguria.

a. Dopamine
b. Dobutamine
c. Isoproterenol
d. Epinephrine

A

20

Mechanism of Action of Milrinone

Phosphodiesterase 3 Inhibitor causing increased cAMP

21

Effects of Milrinone

Increased myocardial contractility

Promotes Vasodilation

22

Mechanism of Action of Nesiritide

Increases cGMP in smooth msucles