[30] Pharma II Anti-Thrombotics Flashcards Preview

[OS 213] CVS Module > [30] Pharma II Anti-Thrombotics > Flashcards

Flashcards in [30] Pharma II Anti-Thrombotics Deck (22):
1

Contraindications for Beta Blockers

Hypotension
Bradycardia
Asthma
LV Dysfunction

2

What can you give to prevent remodeling of the Left Ventricle

ACE Inhibitors

3

What do you give to reduce the risk of recurrent coronary artery thrombosis

Antiplatelet Therapy

4

Statin therapy should be started at a low dose or high dose?

High Dose

5

Heparins biologic activity is dependent on?

Antithrombin

6

Difference of LMWH compared to Unfractionated Heparin

Heparin inhibits: Thrombin, IXa and Xa

LMWH inhibits: Thrombin alone

7

Anti-Platelet Therapy commonly uses this drug

Aspirin

8

How should you take an Aspirin tablet?

Chewed or crushed quickly

9

[Bivalirudin]

Clinical Use

Heparin alternative in PCI patients

10

[Coumarin]

Clinical Use

Treatment of embolism, DVT, AF

11

[Coumarin]

Mechanism of Action

Inhibits synthesis of factors II, VII, IX, and X

Inhibits production of Vitamin K

12

[Coumarin]

Contraindications

Hemophilia
Pregnancy

13

[Coumarin]

Overdose Treatment

Vitamin K

Phytonadione

14

An ideal fibrinolytic agent with a short half life that is recommended in the West

Alteplase

15

Inhibitors of Fibrinolysis

Aminocaproic Acid
Tranexamic Acid
Aprotinin

16

Mechanism of Action of Aminocaproic Acid

Competitive lysine inhibitor

17

Mechanism of Action of Aprotinin

Serine protease inhibitor

18

Examples of Direct Thrombin Inhibitors that bind to both catalytic sites and substrate recognition site

Hirudin
Bivalirudin

19

Small molecules that bind only at the thrombin active site

Argatroban
Melagatran

20

In case of Heparin Overdose you give?

Protamine Sulfate

21

Mechanism of Action of Aspirin

Irreversible Cyclooxygenase Inhibitor

(Specifically prevents the creation of Thromboxane A2)

22

Mechanism of Action of Dipyridamole

Lower platelet calcium
Increases cAMP formation