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Myco-Viro > (2) Herpes, and Poxvirus > Flashcards

(2) Herpes, and Poxvirus Flashcards

(113 cards)

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1
Q

Cytomegalovirus (CMV)

Official name

A

Human Herpesvirus 5

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2
Q

Cytomegalovirus (CMV)

Most common cause of

A

iral congenital infection (Infection of the newborn babies)

can lead to severe abnormalities

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3
Q

Cytomegalovirus (CMV)

nfection is common during?

A

during childhood and adolescence

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4
Q

Cytomegalovirus (CMV)

infections are typically?

A

asymptomatic

(severe infections can occur in immunocompromised patients)

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5
Q

Cytomegalovirus (CMV)

Mode of transmission

A

transplacental, oral, sexual and by blood and tissue transplant

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6
Q

CMV: Pathogenesis

what happen when the virus is acquired from the blood, tissue or other body fluids

A

CMV cause a productive infection of the epithelial cells

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7
Q

CMV: Pathogenesis

In immunoncompromised patients, reactivating CMV diseases develops?

A

severe presentation

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8
Q

CMV: Pathogenesis

Site of latency

A

T-cells, macrophages, monocytes, and renal tubules

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9
Q

CMV: Clinical Manifestation (findings)

Enumerate the disease involve:

A
  • Congenital Infection
  • Postnatal Infection
  • pneumonitis, gastrointestinal infection and encepalopathy
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10
Q

CMV: Clinical Manifestation (findings)

Can result in death of the fetus in utero

A

Congenital Infection

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11
Q

CMV: Clinical Manifestation (findings)

for congenical infection, the Cytomegalic inclusion disease of newborns Characterized by

A

involvement Of the central nervous system and reticuloendothelial systems

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12
Q

CMV: Clinical Manifestation (findings)

clinical findigns under the congenital infection

A
  • ntrauterine growth
  • retardation
  • jaundice
  • hepatosplenomegaly
  • thrombocytopenia
  • microcephaly
  • retinitis
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13
Q

CMV: Clinical Manifestation (findings)

infections mononucleosis like illness (heterophil antibody negative)

A

Postnatal infection

main distinction from IM of the EBV

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14
Q

CMV: Clinical Manifestation (findings)

TOF

Signs and symtoms are alike with IM of the EBV

A

T - heterophil antibody negative yung main difference

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15
Q

CMV: Clinical Manifestation (findings)

pneumonitis, gastrointestinal infection and encepalopathy

A

Immunocompromised Patients

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16
Q

Lab Diagnosis: CMV

enumerate

A
  1. Isolation of Virus
  2. Direct Microscopy Examination
  3. Serology
  4. Molecular Assay
  5. Antigemia Test- Rapid test in serology
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17
Q

Lab Diagnosis: CMV (isolation)

what should be isolated from the virus?

A

Human Diploid Fibroblast (HDF) cell

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18
Q

Lab Diagnosis: CMV (isolation)

appearance of cytologic changes occurs after 2-3 weeks

A

Human Diploid Fibroblast (HDF) cel

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19
Q

Lab Diagnosis: CMV (isolation)

Cytopathic effect?

A

SWOLLEN TRANSLUCENT CELLS WITH LARGE INTRANUCLEAR INCLUSION

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20
Q

Lab Diagnosis: CMV (isolation)

For rapid method

A

DEAFF TEST (Detection of early antigen fluorescent foci)

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21
Q

Lab Diagnosis: CMV (isolation)

process of DEAFF Test

A

Specimen is inoculated into cell culture and examined after 24 hours by immunofluorescence for expressed CMV encoded early proteins (this is what looked for)

Viral proteins fluoresce

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22
Q

Lab Diagnosis: CMV (Direct microscopic)

what are the specimen for GIEMSA Stain

A

Urine or tissue

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23
Q

Lab Diagnosis: CMV (Direct microscopic)

what inclusion should be seen from PAP or Giems stain (Urine/tissue)

A

“OWL EYE” inclusion

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24
Q

Lab Diagnosis: CMV (Serology)

ANtibody tests

A

serology

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25
# Lab Diagnosis: CMV (Serology) present infection and also found in patients with reactivation
CMV IgM
26
# Lab Diagnosis: CMV (Serology) past infection
CMV IgG
27
# Lab Diagnosis: CMV what molecular assay technique can be used
PCR - can provide quantitativeviral load in the blood, CSF, and urine
28
# Lab Diagnosis: CMV Antigemia Test- Rapid test in serology, what should be detected
CMV PP65
29
# Lab Diagnosis: CMV (antifemia) CMV PP65 should be detected in?
Detected in nuclei or peripheral blood neutrophils
30
# CMV: Treatment, Prevention and Control TOF Screening of transplant donors and recipients for CMV antibody may prevent some transmissions of primary CMV
True
31
# CMV: Treatment, Prevention and Control immunocompromised patient can take what medicine?
ganciclovir, forscarne, and cidofovir | antiviral drugs
32
# Human Herpes Virus 6 (HHV-6) first recognized in what year?
1986
33
# Human Herpes Virus 6 (HHV-6) Genome of the virus resembles that of ?
human CMV
34
# Human Herpes Virus 6 (HHV-6) Mode Of transmission
Oral secretions
35
# HHV-6: Pathogenesis When the virus is present in the saliva, it causes an infection in the
oropharynx
36
# HHV-6: Pathogenesis The virus will grow well in the
CD4 T - lymphocytes
37
# HHV-6: Pathogenesis The virus will grow well in the CD4 T - lymphocytes and can also replicate in
- B-cells - cells of glial - fibroblastoid - megakaryocyte origin
38
# HHV-6: Pathogenesis important cellular receptor
HUMAN CD46
39
# HHV-6: Clinical Manifestation Roseola infantum, or "sixth disease" of childhood
Exanthem Subitum
40
# HHV-6: Clinical Manifestation exanthem subitum are mild common childhood disaese characterizeed by?
high fever and skin rash
41
# HHV-6: Clinical Manifestation reactivation is common in?
transplant patients and during pregnancy
42
# HHV-6: Clinical Manifestation reactivation is common in transplant patients and during pregnancy and may cause
encephalitis, pneumonitis, or chorioretinitis
43
# Lab Diagnosis: HHV-6 basis for diagnosis?
Clinical findings
44
# Lab Diagnosis: HHV-6 TOF Culture- practical
F (not practical) ## Footnote Lab Diagnosis: HHV-6
45
# Lab Diagnosis: HHV-6 TOF kantology — IgM (present infection) and IgG (past infection)
F (serology)
46
# Human Herpes Virus 7 (HHV-7) also known as:
T-Lymphotropic Human Herpesvirus
47
# Human Herpes Virus 7 (HHV-7) First isolated in
1990
48
# Human Herpes Virus 7 (HHV-7) isolated from
acitvated T cells
49
# Human Herpes Virus 7 (HHV-7) where was the activated t cells recovered?
**peripheral blood lymphocytes** of a healthy individual
50
# Human Herpes Virus 7 (HHV-7) Infections commonly occur during
childhood along with **HHV - 6**
51
# Human Herpes Virus 7 (HHV-7) Persistent infection is established in the
Salivary glands
52
# Kaposi Sarcoma Herpes Virus (KSHV) Official name
Human Herpes Virus -8 (HHV-8)
53
# Kaposi Sarcoma Herpes Virus (KSHV) Lymphotropic closely related to?
EBV
54
# Kaposi Sarcoma Herpes Virus (KSHV) Mode of transmission
Contact with oral secretions
55
# Kaposi Sarcoma Herpes Virus (KSHV) it can cause?
Kaposi sarcoma - vascular tumors of mixed cellular composition
56
# Kaposi Sarcoma Herpes Virus (KSHV) Kaposi sarcoma is commonly involved in the pathogenesis of body cavity-based lymphomas occurring in whose patients
AIDS patients and Of multicentric Castleman disease
57
# Kaposi Sarcoma Herpes Virus (KSHV) number 1 cancer of ?
aids patient
58
# Kaposi Sarcoma Herpes Virus (KSHV) diagnosis is made through using?
antibodies
59
# Kaposi Sarcoma Herpes Virus (KSHV) Diagnosis used to measure antibodies to KHSV:
Serological assays:
60
# Kaposi Sarcoma Herpes Virus (KSHV) what serological assays could be use?
- indirect immunofluorescence - Western blot - enzyme - linked immunosorbent assay may be used to measure
61
# Poxvirus give the characteristic
- dSDNNA - Enveloped - Complex - Linear
62
# Poxvirus shape
BRICK-SHAPED
63
# Poxvirus TOF Largest plant virus
F (animal)
64
# Poxvirus inclusion
GUARNIERI BODIES | use electron micrscopy
65
# Poxvirus saan makikita lesions
Vesicular skin lesion in the susceptible host
66
# Poxvirus Replication occurs in the
Cytoplasm
67
# Poxvirus Pox virus the cause disease to human
SMALLPOX
68
# Smallpox Caused by
VARIOLA VIRUS of the genus ORTHOPOXVIRUS
69
# Smallpox what are the 2 main forms of Variola virus
- Variola Major: causative agent of small pox - Variola Minor: causative agent of ALASTRIM (milder from of smallpox)
70
# Smallpox causative agent of small pox
Variola major
71
# Smallpox causative agent of alastrim (milder from of small pox)
Variola minor
72
# Smallpox The name Of the disease is derived from the latin word
'spotted'
73
# Smallpox spotted means?
which to the raised bumps that appear on the face and body of an infected person
74
# Smallpox - History Earliest record of smallpox infection
Egypt, 2000BC
75
# Smallpox - History Widespread of infection in India
1st century BC
76
# Smallpox - History Widespread of infection in Asia and Europe
800 AD
77
# Smallpox - History Eradication of the infection as declared by WHO
1978
78
# Smallpox - History Mode of transmission
Aerosol and droplets from respiratory secretions
79
# Smallpox - Pathogenesis and clinical manifestation Upon inhalation of the virus due to large droplets, will enter
upper respiratory system
80
# Smallpox - Pathogenesis and clinical manifestation Incubation
10-14 days (12 days average)
81
# Smallpox - Pathogenesis and clinical manifestation Primary infection and multiplication happens in the
Lymphoid tissue
82
# Smallpox - Pathogenesis and clinical manifestation then lymphoid tissue which will drain the site of entry, and later on will result to
“transient viremia” or temporary viremia
83
# Smallpox - Pathogenesis and clinical manifestation Infection in the reticuloendothelial cell will make abot to the
liver, spleen, and lungs
84
# Smallpox - Pathogenesis and clinical manifestation Secondary phase of multiplication will occur in the
reticuloendothelial cell
85
# Smallpox - Pathogenesis and clinical manifestation Secondary phase of multiplication will occur in the reticuloendothelial cell that will lead to
secondary more intense viremia
86
# Smallpox - Pathogenesis and clinical manifestation on the clinical manifestation stage what will appear
Rash
87
# Smallpox - Pathogenesis and clinical manifestation refer sa table for manifestation
okay
88
# Lab Diagnosis: Smallpox Specimen of choice for viral detection and isolation.
Skin lesions
89
# Lab Diagnosis: Smallpox Direct examination of clinical material using ____ ____may be used for rapid identification of virus particles
electron microscopy
90
# Lab Diagnosis: Smallpox for cell culture what is used as specimen and where is it cultured
Specimen: Vesicular fluid Medium: chorioallontoic membrane of chick embryos
91
# Lab Diagnosis: Smallpox what is the goal for cell culture
Differentiate smallpox from generalized vaccinia
92
# Lab Diagnosis: Smallpox after 2 to 3 days, small pocks are produced sa cell culture
Smallpox
93
# Lab Diagnosis: Smallpox large, necrotic pocks
Vaccinia
94
# Lab Diagnosis: Smallpox Viral antigens in vesicle fluid can be detected by precipitin tests or immunofluorescent
Serology
95
# Lab Diagnosis: Smallpox A 4-fold increase in antibody titer in convalescent serum phase is diagnostic
Antibody assays
96
# Smallpox - Treatment, Prevention and Control Treatment of smallpox infection is
mainly supportive
97
# Smallpox - Treatment, Prevention and Control TOF immunization
T
98
# Smallpox - Treatment, Prevention and Control Earliest attempt is of immunization
thru variolation
99
# Smallpox - Treatment, Prevention and Control TOF 1796 - Edward Jenner introduced vaccination with cowpox virus
T (go back to the history with lec 1 ha)
100
# Smallpox - Treatment, Prevention and Control vaccination’ comes from the latin word
cow “vacca”
101
# Smallpox - Treatment, Prevention and Control The vaccine for smallpox infection comes from the
Vaccinia virus
102
# Smallpox - Treatment, Prevention and Control Vaccinia virus which is prepared from
vesicular lesions ("lymph")
103
# Smallpox - Treatment, Prevention and Control vesicular lesions ("lymph") produced in the skin Of
calves or can also be grown in chick embryos
104
Does not cause smallpox infection but is associated with tenderness and fever
Vaccinia Virus
105
Source of vaccine for smallpox
Vaccinia Virus
106
Causes zoonotic infection from sheep
Parapoxviruses: ORF VIRUS
107
# Parapoxviruses: ORF VIRUS TOF Causes a purulent-appearing papule locally and generally systemic symptoms.
F (no systemic symptoms)
108
# nfected areas includes the Infected areas includes the
- finger - hand - arm - face
109
Common, benign viral infection of the skin and mucous membranes
Molluscipox: MOLLUSCUM CONTAGIOSUM
110
# Molluscipox: MOLLUSCUM CONTAGIOSUM ommonly affecting children of ages
1 to 10
111
# Molluscipox: MOLLUSCUM CONTAGIOSUM Spread of infection happens due to a
direct skin-to-skin contact with the infected individual
112
# Molluscipox: MOLLUSCUM CONTAGIOSUM Lesions in the affected skin presents as
umbilicated papul
113
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