ASA

Question 1

ASA- names

Answer 1

Acetylsalicylic Acid,

Aspirin

Question 2

ASA- Class

Answer 2

Analgesic

Antipyretic

Non-Steroidal Anti-Inflammatory Drug (NSAID)

Platelet Aggregate Inhibitor

Question 3

ASA- MoA

Answer 3

Inhibits aggregation (clumping) of platelets by blocking the formation of the substance thromboxane (A2); prolonging bleeding time

Provides analgesia by inhibiting prostaglandins and other substances that sensitize pain receptors (blocking of prostaglandins also accounts for the drug’s anti-inflammatory effects).

Relieves fever by acting upon the hypothalamic heat regulating center

Question 4

ASA- Indications

Answer 4

Suspected MI

Thrombotic stroke

AFIB/AFLU

Question 5

ASA- Contra

Answer 5

Active gastrointestinal bleeding

Relative Contraindication: Asthma patients with nasal polyps (anaphylaxis is common)

Question 6

ASA- S/E

Answer 6

Gastrointestinal: bleeding, heartburn, epigastric pain

CNS: dizziness, confusion, drowsiness

ENT: tinnitus, hearing loss

Other: may impair renal function, may prolong labor in pregnancy with increased bleeding

Question 7

ASA - Routes

Answer 7

PO

Question 8

ASA- A DOSE

Answer 8

162-325 mg PO

Question 9

ASA - P Dose

Answer 9

not recommended

Question 10

ASA- EXTRAs

Answer 10

Precautions: Medical history of pre-existing ulcers, liver disease or bleeding disorders

Due to the possible association of aspirin with Reye’s syndrome, do not give drug to children or teenagers with signs and symptoms of chickenpox (varicella) without physician consultation

Interactions: inhibits anti-hypertensive effects of ACE inhibitors

Ammonium chloride and other urine acidifying drugs will increase effects of aspirin – watch for toxicity

Onset is 5-30 minutes and may last 1-4 hours, peak in 15 min.