Morphine Sulfate

Question 1

Morphine Sulfate- Name

Answer 1

MS

Question 2

Morphine Sulfate- Class

Answer 2

Opioid Narcotic

CNS Depressant

Question 3

Morphine Sulfate- MoA

Answer 3

Alters pain perception and produces euphoria

Decreases myocardial oxygen demand by decreasing preload (venous pooling due to peripheral vasodilation) and decreasing afterload (decreased systemic vascular resistance due to peripheral vasodilation)

Depresses the CNS by interacting with opiate receptors in the brain

Question 4

Morphine Sulfate- Indications

Answer 4

Moderate to severe pain

Chest pain of suspected myocardial origin

Pulmonary Edema from CHF with or without chest pain

Burns

Question 5

Morphine Sulfate- Contra

Answer 5

Altered level of consciousness

Abdominal pain of unknown etiology (relative)

Patients at risk of respiratory depression

Head injury Hypovolemia

Question 6

Morphine Sulfate- S/E

Answer 6

Cardiovascular: bradycardia, hypotension, (rebound tachycardia/hypertension)

Neurological: sedation, agitation, tremors/seizures, hallucinations

Respiratory: depression, arrest

Gastrointestinal: nausea/vomiting

Question 7

Morphine Sulfate- Routes

Answer 7

IV, IO, IM, PO

Question 8

Morphine Sulfate- A. Dose

Answer 8

Pain Relief:

1.0 – 10.0 mg IV/PO titrated to pain relief

or 5.0 – 10.0 mg IM as a single dose only

Pulmonary Edema:

5.0 – 10.0 mg slow IV push (2.0 mg/minute)

Question 9

Morphine Sulfate- P. Dose

Answer 9

0.1 – 0.2 mg/kg slow IV push (1.0 mg/minute)/PO titrated to pain relief

or 0.2 mg/kg IM

Question 10

Morphine Sulfate- EXTRAS

Answer 10

Precautions: Morphine Sulfate is an opiate derivative – Naloxone should be available to reverse any severe respiratory side effects

Interactions: Use with caution with patients taking other analgesics, depressants or narcotics

IV/IO/PO will have an onset of 2-5 minutes and IM will have an onset of 5-10 minutes.

Each will last approximately 3-5 hours

May draw 10 mg (1 ml) into a 10 ml syringe and mix with 9 ml of Normal Saline. This creates a 1 mg/1 ml concentration for better control when administering the medication.