Promethazine

Question 1

PROMETHAZINE- Name

Answer 1

Phenergran

Question 2

PROMETHAZINE- Class

Answer 2

Antihistamine

Anti-emetic

Phenothiazine

Question 3

PROMETHAZINE- MoA

Answer 3

Competitively blocks histamine receptors in the GI tract

Blocks cholinergic receptors in the vomit centers

Increases acetylcholine action on GI smooth muscles

Question 4

PROMETHAZINE- Indications

Answer 4

Nausea/vomiting

Motion sickness

Potentiates effects of analgesics

Sedation

Question 5

PROMETHAZINE- Contra

Answer 5

Patients who have received large amounts of depressants

Question 6

PROMETHAZINE- S/E

Answer 6

Cardiovascular: tachycardia, bradycardia

Neurological: dizziness, drowsiness, blurred vision, mental and physical impairment

Question 7

PROMETHAZINE- Routes

Answer 7

IV, IO, IM

Question 8

PROMETHAZINE- A. Dose

Answer 8

12.5 - 25 mg

Question 9

PROMETHAZINE- P. Dose

Answer 9

0.25 – 0.5 mg/kg

Question 10

PROMETHAZINE- EXTRAS

Answer 10

Precautions: May cause dystonic reactions

Interactions: Significant CNS depression may occur when patient is also using/receiving barbiturates, narcotics, alcohol or tranquilizers

Onset in 30-60 minutes and may last 4-6 hours