Mannitol

Question 1

Mannitol- Name

Answer 1

Osmitrol

Question 2

Mannitol- Class

Answer 2

Osmotic Diuretic

Question 3

Mannitol- MoA

Answer 3

Inhibits sodium and water absorption in the kidneys

Promotes fluid movement from the intracellular into the extracellular space

Dehydrates brain tissue to decrease ICP

Question 4

Mannitol- Indication

Answer 4

Acute cerebral edema

Blood transfusion reactions

Question 5

Mannitol- Contra

Answer 5

Acute pulmonary edema

Severe pulmonary congestion

Hypovolemia

Question 6

Mannitol- S/E

Answer 6

Cardiovascular: chest pain

Neurological: mental status change

Question 7

Mannitol- Routes

Answer 7

IV, IO, IVPB

Question 8

Mannitol- A. Dose

Answer 8

1.5 – 2 gm/kg

slow IV infusion

Question 9

Mannitol- P. Dose

Answer 9

0.25 – 0.5 gm/kg

over 60 minutes

Question 10

Mannitol- EXTRAS

Answer 10

Precautions: May cause transient increase in intravascular volume

May cause CHF May cause sodium depletion (hyponatremia)

Will crystallize in low temperatures

Should be used with in-line filters

Interactions: Should not be administered during blood transfusions

Onset in 15 minutes to reduce ICP, 1-3 hours for diuresis; may last 3-8 hours