Diphenhydramine

Question 1

Diphenhydramine- Name

Answer 1

Benadryl

Question 2

Diphenhydramine- Class

Answer 2

Antihistamine

Antidyskinetic (anticholinergic)

Sedative/Hypnotic

Question 3

Diphenhydramine- MoA

Answer 3

Competes with histamine receptor sites

CNS depressant and anticholinergic

Question 4

Diphenhydramine- Indications

Answer 4

Allergic symptoms

Dystonic reactions or extrapyramidal symptoms

Question 5

Diphenhydramine- Contra

Answer 5

Acute asthma (relative contraindication)

Nursing mothers

Glaucoma

Question 6

Diphenhydramine- S/E

Answer 6

Cardiovascular: tachycardia, hypotension, palpitations

Neurological: drowsiness, seizures

Respiratory: mucus plugs, wheezing

Question 7

Diphenhydramine- Routes

Answer 7

IV, IO, IM, PO

Question 8

Diphenhydramine- A. Dose

Answer 8

25-100 mg slow IVP/IO (25 mg per minute) or deep IM

Question 9

Diphenhydramine- P. Dose

Answer 9

1 mg/kg slow IVP/IO (25 mg per minute) or deep IM

Question 10

Diphenhydramine- EXTRAS

Answer 10

Precautions: May precipitate an acute asthma attack due to thickening of the mucosal secretions. However, it should not be withheld from a patient having an allergic reaction simply due to a history of asthma

May increase intra-ocular pressure

Interactions: Use with caution for patients on sedatives, tranquilizers or alcohol

Onset in 1-15 minutes depending upon route used and may last 3-4 hours