Magnesium Sulfate

Question 1

Magnesium Sulfate- Name

Answer 1

Mag Sulfate

Question 2

Magnesium Sulfate- Class

Answer 2

Electrolyte

Antidysrhythmic

Anticonvulsant

CNS Depressant

Question 3

Magnesium Sulfate- MoA

Answer 3

Decreases Acetylcholine in motor nerve terminals

Produces neuromuscular blockade in the CNS

Physiological Calcium Channel Blocker

Question 4

Magnesium Sulfate- Indications

Answer 4

Refractory VFIB/pulseless VTAC(ACLS)

Treatment for Torsades de Pointes (polymorphic VTAC)

Seizures associated with eclampsia and alcohol withdrawal

Dysrhythmias associated with digitalis toxicity

Bronchospasms refectory to traditional medications

Question 5

Magnesium Sulfate- Contra

Answer 5

Cardiogenic shock

Heart blocks

Question 6

Magnesium Sulfate- S/E

Answer 6

Cardiovascular: dysrhythmias, bradycardia, hypotension, heart blocks

Neurological: drowsiness

Respiratory: decreased respiratory rate, respiratory paralysis

Other: flushing, sweating

Question 7

Magnesium Sulfate- Routes

Answer 7

IVP, IO, IM, IVPB

Question 8

Magnesium Sulfate- A. Dose

Answer 8

1-4 g in 50-100 ml Normal Saline

IVPB/IVP

over 5 minutes

Question 9

Magnesium Sulfate- P. Dose

Answer 9

20-50 mg/kg in 50-100 Normal Saline

IVPB

Maximum single dose is 2 g

Question 10

Magnesium Sulfate- EXTRAS

Answer 10

Precautions: Patients with renal insufficiency/disease (excreted through the kidneys)

Interactions: Other CNS depressants, digitalis and neuromuscular blockers

Onset in 3-5 minutes and may last 30 minutes

Calcium Chloride can be used as an antidote should respiratory depression occurs.

In clinical trials as a neuro-protective drug for CVA patients.