Midazolam

Question 1

Midazolam- Name

Answer 1

Versed

Question 2

Midazolam- Class

Answer 2

Anticonvulsant

Amnesic Agent

Anti-anxiety (anxiolytic)

Benzodiazepine

Sedative/hypnotic

Tranquilizer

Question 3

Midazolam- MoA

Answer 3

1. Binds to benzodiazepine receptors
2. Increases the inhibitory neurotransmitter GABA leading to decreased agitation, relaxation of skeletal muscles, and in high doses sleep.

Question 4

Midazolam- Indications

Answer 4

Seizures

Premedication for synchronized cardioversion/TCP

One of the premeditations for RSI

Anxiety Disorder

Question 5

Midazolam- Contra

Answer 5

Acute narrow-angle glaucoma

Shock (from hypovolemia)

Hypotension (from hypovolemia)

Alcohol or drug intoxication

Question 6

Midazolam- S/E

Answer 6

Cardiovascular: bradycardia, rebound tachycardia, hypotension

Neurological: amnesia, drowsiness, agitation, ALOC

Respiratory: respiratory depression or arrest

Gastrointestinal: nausea/vomiting

Question 7

Midazolam- Routes

Answer 7

IV, IO, IM, IN

Question 8

Midazolam- A. Dose

Answer 8

Pre-cardioversion or transcutaneous pacing:

1.0 – 2.5 mg slow IV/IO/IN

Seizure:

0.1 mg/kg slow IV/IO/IN

or 0.2 mg/kg IM

to a maximum of 5.0 mg

Question 9

Midazolam- P. Dose

Answer 9

Seizure:

0.1 mg/kg slow IV/IO/IN

or 0.2 mg/kg IM

to a maximum of 5.0 mg

Question 10

Midazolam- EXTRAS

Answer 10

Precautions: Elderly patients with impaired respiratory function

Patients with renal failure, liver failure or COPD

Interactions: Other CNS depressants or benzodiazepines

Onset in 1-5 minutes (IV/IO/IN) or 5-15 (IM) and may last 2-6 hours