Diltiazem Hydrochloride

Question 1

DILTIAZEM HYDROCHLORIDE- Name

Answer 1

Cardizem

Question 2

DILTIAZEM- Class

Answer 2

Calcium Channel Blocker

Antidysrhythmic

Antihypertensive

Question 3

DILTIAZEM- MoA

Answer 3

Inhibits calcium influx across cellular membranes

Coronary artery dilation – increasing myocardial oxygen delivery

Smooth muscle relaxation – decreases peripheral vascular resistance

Slows SA/AV node conduction

Question 4

DILTIAZEM- Indications

Answer 4

Symptomatic AFIB/AFLU

SVT/PSVT

Question 5

DILTIAZEM- Contra

Answer 5

23 90 SAW

BP < 90 mmHg systolic

2nd and 3rd degree heart blocks

Sick Sinus Syndrome

AMI

Wolf-Parkinson-White Syndrome

Question 6

DILTIAZEM- S/E

Answer 6

Cardiovascular: bradycardia, hypotension, CHF, heart blocks

CNS: dizziness, drowsiness, confusion

Question 7

DILTIAZEM- Routes

Answer 7

IV, IO

Question 8

DILTIAZEM- A. Dose

Answer 8

15-20 mg IVP/IO

Question 9

DILTIAZEM- P. Dose

Answer 9

0.25 mg/kg IV push over 2-5 min;

repeat at 0.35 mg/kg if no response/improvement in 15 minutes.

Max dose of 3.5 mg/kg in a 24 hour period.

Question 10

DILTIAZEM- EXTRAS

Answer 10

Precautions: CHF and renal disease

Interactions: Ensure patient is not taking Beta Blockers or received IV calcium channel blockers because of the increased risk of CHF, bradycardia and asystole

Onset in 30-60 minutes and may last 3-9 hours