2.8 & 2.9 Protein Digestion Flashcards Preview

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Flashcards in 2.8 & 2.9 Protein Digestion Deck (27):
0

Name the ketogenic Essential AA

Leucine and Lysine

1

Name the Non-Essential Ketogenic AA

NONE

2

Name the Glucogenic Essential AA

Histidine, THreonine, Methionine and Valine

3

Name the Glucogenic and Ketogenic Essential AA

Isoleucine
Tryptophan
Pheynlalanine

4

Name the Non essential Glucogenic and Ketogenic AA

Tyrosine

5

What is ketogenic?

An amino acid that is degraded to Acetyl-CoA or Oxaloacetate.
Cannot be converted to glucose

6

Role of HCl in protein digestion

Reduces pH to 1-2 which allows denaturation of dietary proteins

7

What activates Pepsin?

Low pH and other active autoactivate pepsin as well

8

Cholescystokinin is stimulated how in protein digestion and what are its function

It is stimulated by protein leaving the stomach
It stimulates release of pancreatic enzymes
It stimulates release of bile
It stimulates slow gastric empyting

9

Role of Secretin in Protein digestion

Activates release of bicarbonate solution from pancreas to neutralize the pH of intestine

10

What is the role of Enteropeptidase?

To convert trypsinogen to its active form trypsin

11

T or F, Pancreatic enzymes are released into small intestine as zymogens

True

12

What catalyzes Pepsinogen --> Pepsin

Low pH or other active pepsin

13

What is the role of pepsin

Degrade large peptide fragments and some free amino acids

14

What catalyzes Chymotrypsinogen --> CHymotrypsin

Tryspin

15

What substrates does chymotrypsin act on?

Aromatic Amino Acids

16

What does Trypsin digest?

Arginine and Lysine residues

17

Elastase has substrate specificity for what?

Hydrophobic Amino acids

18

What are the major end products of protein digestion?

Free Amino Acids
Dipeptides
Tripeptides

19

How are dipeptides and tripeptides transported across intestinal cell?

By using an H+ symporter

20

How are Free Amino Acids transported into intestinal cell?

Using a Na Symporter

21

How are all amino acids taken up by the capillary?

By using a Na Symporter

22

What is Ubiquitin?

It is a marker that tags proteins for degradation by the proteasome

23

T or F, Few Amino Acids are reincorporated into new proteins within the body

False, Most amino acids are.

24

What are the three determinants of Protein longevity

Oxidation
PEST Sequences
Amino Terminal Residues

25

What is the significance of Amino Terminal residues?

Some have high stabalizing residues while others have destabalizing. This determines the longevity of the AA

26

What are the 4 PEST Sequences

Glutamate
Proline
Serine
Threonine