29. Varicella-zoster virus. Herpangina.

Question 1

Definition of Varicella Zoster Virus

Answer 1

• Causes acute self limiting viral infection
• Usually affects sensory nerves

Question 2

Etiology of Herpes Zoster Virus

Answer 2

• Varicella zoster virus or Herpes virus type 3

Question 3

Clinical features of Herpes Zoster

Answer 3

• Fever, headache and malaise
• Regional lymphnodes enlarged and tender
• Oral lesions-vesicles w/ erythematous base
• Evolve into pustules and ulcers covered by crusts

Question 4

Diagnosis of Herpes zoster

Answer 4

History and clinical features

Question 5

Laboratory tests for Herpes zoster

Answer 5

Cytologic and histopathologic examination

Question 6

Differential diagnosis of Herpes zoster

Answer 6

• Herpes simplex
• Herpangina
• Erythema multiforme
• Varicella

Question 7

Treatment of Herpes Zoster

Answer 7

* Antivirals (brivudine, valacyclovir, and famciclovir) are the first
line of treatment
* Analgesics and sedatives to control the pain
Prednisolone (20–30 mg for about 8–10 days) reduces the risk for postherpetic neuralgia.

Question 8

Definition of Herpangina

Answer 8

• Acute self limiting viral infection
• Affects children and young adults

Question 9

Etiology of Herpangina

Answer 9

• Coxsackievirus(group A)
• Types 1-6, 8, 10 , 22

Question 10

Clinical features of Herpangina

Answer 10

• Sudden fever-headache, malaise, nausea, sore throat
• Oral mucosa- vesicles that rupture leaving shallow ulcers
• Located soft palate, uvula, tonsillar pilars, posterior pharyngeal wall

Question 11

Diagnosis of Herpangina

Answer 11

History and clinical features

Question 12

Laboratory tests for Herpangina

Answer 12

Usually not required

Question 13

Differential diagnosis of Herpangina

Answer 13

• Primary herpetic gingivostomatitis
• Herpetiform ulcers
• Acute lymphonodular pharyngitis

Question 14

Treatment of Herpangina

Answer 14

Symtomatic