33-Limbic Flashcards Preview

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Flashcards in 33-Limbic Deck (73)
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1

limbic system involved in (x5)

- emotions
- memory
- sexual arousal
- stress
- odor processing

2

limbic system difficult to study because (x2)

- structures are interconnected
- difficult to quantify responses/outcomes

3

hippocampus connects via _____ to _____ and _____

via fornix

to septal nuclei
and mamillary bodies

4

mammillary bodies connect via ___ to ___

via mammillothalamic tract (MTT)

to anterior thalamic nuclei

5

amygdala connects via ___ to ___ and ___

via stria terminalis (ST)

to septal nuclei
and hypothalamus

6

ant thalamic nuclei connects via ___ to ___

via internal capsule (IC)

to cingulate gyrus

7

cingulate connects via ___ to ___

via cingulum

to hippocampus

8

hypothalamus connects via ___ to ___

via dorsal longitudinal fasciculus (DLF)

to brainstem/spinal cord

9

septal nuclei connect
(1) via ___ to ___
and
(2) via ___ to ___

(1) via medial forebrain bundle (MFB)
to hypothalamus

and
(2) via stria medullaris
to habenula

10

Source of norepinephrine innervation on limbic system

locus coeruleus (LC)

11

Source of serotonin (5-HT) innervation on limbic system

raphe nuclei (Ra)

12

Source of dopamine (DA) innervation on limbic system

mesolimbic system

13

Source of acetylcholine (ACh) innervation on limbic system (x2)

septal nuclei, and
nucleus basalis of Meynert

14

Norepinephrine and serotonin modulate (x4)

- mood
- cognition
- sleep/wake cycles
- arousal

15

Mesolimbic dopamine system consists of (x3)

- ventra tegmental area (VTA)
- nucleus accumbens (NAc)
- associated limbic structures (prefrontal cortex, amygdala, hippocampus, hypothalamus)

16

Pathway involved in addiction

mesolimbic dopamine pathway

17

Mesolimbic cholinergic pathway involved in (x2)

- reward/reinforcement
- associative learning

18

VTA

ventral tegmental area

19

Lesions to the VTA and/or NAc lead to

-> blockade of DA receptors -> decreased addictive behaviour

20

drug addiction:
cocaine mechanism

blocks DA reuptake -> incr. DA

21

drug addiction:
amphetamine mechanism

release of DA and blockage of DA reuptake -> incr. DA

22

drug addiction:
heroin/nicotine mechanism

VTA or NAc

23

Natural rewards (sex, food) require

intact mesolimbic pathway

24

amygdala involved in

emotional memories

25

lesions of amygdala impair

consolidation of fear memories

26

during emotional memories, amygdala modulates activity of ___

medial temporal lobe

27

amygdala response to fear

increased (unilateral) activity

28

phenotypes of bilateral amygdala calcification in Urbach-Wiethe disease (x2)

- impairment in neg/pos emotional processing
- memory loss specific to information with emotional context

29

medial prefrontal cortex connected to limbic regions ___ and ___

- hippocampus
and
- amygdala

30

injury to prefrontal cortex leads to (x2)

- impairment in goal directed behavior
- altered moral reasoning and social behavior