25-Motor6-Cerebellum Flashcards Preview

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Flashcards in 25-Motor6-Cerebellum Deck (50)
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1

components of cerebellar cortex (x3)

vermis, intermediate and lateral zones

2

cerebellar nuclei (x4)

fastigial, globose, emboliform, dentate

3

cerebellar peduncles

inferior, middle, superior

4

cerebellum cortical layers (x3)

molecular, purkinje cell, and granular

5

five intrinsic neurons in cerebellar cortex

- purkinje cells: only output neuron, inhibitory (GABA)
- granual cells: origin of parallel fiber system, excitatory (glutamate)
- stellate: inhibit Purkinje cells
- basket: inhibit Purkinje cells
- Golgi: inhibit granual cells
These last three are all inhibitory interneurons, probably all use GABA, excited by parallel fibers

6

basic cerebellar circuit (x4)

- mossy fibers -> granule cells -> Purkinje cells
- climbing fibers -> Purkinje cells
- Purkinje cells -> cerebellar nuclei and vestibular nucleus
- cerebellar nuclei -> many targets in CNS

7

two major classes of inputs

- mossy fibber afferents
- climbing fiber afferents

8

mossy fiber afferents originate from ___

various spinal and brainstem sites

9

climbing fiber afferents originate from ___

contralateral inferior olive only

10

mossy fiber afferents synapse on ___

granule cells (excitatory, glutamate)

11

climbing fiber afferents synapse on ___

Purkinje cells, monosynaptically, excitatory

12

mossy fiber afferents produce [simple/complex] spikes in Purkinje cells

simple

13

climbing fiber afferents produce [simple/complex] spikes in Purkinje cells

complex

14

[True/false]: mossy fiber afferents encode temporal and intensity information

true

15

[True/false]: climbing fiber afferents encode temporal and intensity information

unknown

16

Discharge rate of mossy fiber afferents

50-100 spikes/sec

17

Discharge rate of complex fiber afferents

1-2 spikes/sec

18

Cerebellar cortex is [ipsi/contra]laterally organized

ipsilaterally (unlike motor cortex)

19

[True/false]: climbing fibers are parallel to parallel fibers

false, they are orthogonal

20

Inputs to inferior olive (x3)

- spinal projections
- cerebral cortical inputs
- red nucleus (feedback from cerebellum)

21

[True/false]: complex spikes may signal errors in movement

used to be common hypothesis, recently controversial, false?

22

cerebellar functional divisions (x3)

- vestibulocerebellum
- spinocerebellum
- cerebrocerebellum

23

Vestibulocerebellum:
location

flocculonodular lobe

24

Vestibulocerebellum:
inputs via ___ fibers: (x4)

via mossy fibers
- semicircular canals
- otoliths
- visual info from retina and parietal/occiptal via pontine nuclei
- neck and trunk

25

Vestibulocerebellum:
outputs: (x4)

- vestibular nucleus (medial and lateral) and fastigial nucleus
- medial vestibulospinal tract (which controls trunk/neck muscles)
- lateral vestibulospinal tract (controls limb muscles)
- gaze centers (controls eye movements)

26

Spinocerebellum:
location

intermediate zones and vermis

27

Spinocerebellum:
inputs via ___ fibers: (x2)

via mossy fibers
- spinocerebellar tracts (x3)
-- from trunk/neck muscles
-- dorsal spinocerebellar tract (DSCT)
-- ventral spinocerebellar tract (VSCT)
- face somatosensory/proprioceptive inputs

28

Spinocerebellum:
outputs (x1)

intermediate zone projects to globose and emboliform nuclei
- rubrospinal tract
- corticospinal tract

29

Cerebrocerebellum:
location

cerebellar hemispheres (lateral zones)

30

[True/false]: cerebrocerebellum is largest part of cerebellum

true