4/15 Flashcards

1
Q

Galactosemia signs and inheritance and tx

A
Jaundice
hepatomegaly
vomiting
failure to thrive
cataracts
e.coli sepsis
AR
Soy formula
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2
Q

Congenital rubella signs

A

jaundice, hepatosplenomegaly
cataracts
microencephaly
pda

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3
Q

Gaucher Dz etiology, features,managment

A

AR, Glucobrosidase def, acumulation in macrophages

splenomegaly
hepatomegaly
bone pain
failure to thrive
delayed puberty 
anemia 
thrombocytopenia
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4
Q

GI complication of HSP

A

intussuception

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5
Q

post amputation pain weeks to months later

A

post traumatic neuroma

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6
Q

what do papillary thyroid tumors look like

A

large cells with ground glass cytoplasm and pale nuclei containing inclusion bodies and central grooving

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7
Q

only modifiable risk factor associated with crohns severity

A

smoking

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8
Q

GI thing that increases risk for diverticulosis

A

obesity. Diabeties does not

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9
Q

succunylcholine SE

A

cardiac affhthmia from hyper k. sodium influx k outflux

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10
Q

watershed areas colon

A

spleni. flexure

rectosigmoid junction

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11
Q

what gifts can be accepted from pharmaceutical companies

A

small ones that directly benifit patient care

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12
Q

test prior to starting transtuzumab

A

echo

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13
Q

ptt in antiphospholipid antibody syndrome

A

increased, binds to testing assay

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14
Q

imantinib moa

A

tyrosine kinase inhibitor

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15
Q

conditions associated with diabetes 1

A

Rubella
coxsackie
mumps

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16
Q

Biguanide example, MOA, SE

A

metformin
Decrease hepatic gluconeogenesis, increases insulin sensitivity
GI disturbances, lactic acidosis, decreased b12 absorption, contraindicated in liver and kidney failure

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17
Q

Sulfonylureas example, MOA, SE

A

glyburide
stimulates insulin release
Hypoglycemia, contraindicated hepatic or renal failure

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18
Q

Thiazolidiones example, MOA, SE

A

pioglitazone
increase insulin sensitivity, decrease liver production
weight gain, fluid retention, increase ldl, contraindicated chi

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19
Q

DPP IV inhibitors example, MOA, SE

A

sitagliptin
inhibits incretin depredation, = decrease glucagon =increased insulin
diarrhea, constipation, edema

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20
Q

SGLT2 inhibitors example, MOA, SE

A

dapagliflozin
inhibits renal absorption of glucose
genital fungal infections, uti, mild hypoglycemiaw

21
Q

which thyroid cancer makes calcitonin

22
Q

what affect does calcitonin have on bone reabsorption

23
Q

anterior pituitary hormones

A

ACTH, GH , Prolactin, TSH, FSH, LH

24
Q

posterior pituitary hormones

A

ADH, Oxytocin

25
Excess prolactin results in _____ FSH and LH
Decreased
26
What is elevated acromegaly
IGF-1
27
TX for acromegaly
dopamine agonists or octreotide
28
Zona Glomerulosa stimulation, secretly products, result
RAS Aldosterone conserves Na maintains fluid volume
29
Zona Fasciculata stimulation, secretly products, result
ACTH Cortisol Maintains glucose production, fat metabolism, immune response, nervous regulation
30
Zona Reticularis stimulation, secretly products, result
ACTH Androgens 2ndary sex characteristic, bone and muscle mass, male sexual differentiation and sperm production
31
Medulla stimulation, secretly products, result
Preganglionic sympathetic neurons epi/norepi sympathetic effects (glucose mobilization, increased contractility, and increases HR)
32
K+ and pH in cushings
decreased, metabolic alkalosis
33
sx of cortisol excess first test
overnight low dose dexamethasone suppression
34
low cortisol following overnight low dose dexamethasone suppression
sx not due to intrinsic cause, probably too much exogenous administration
35
no change in cortisol following low dose dexamethasone suppression, next test
24 hr free urinary cortisol test
36
normal 24 hr free urinary cortisol test
not cushings
37
high 24 hr free urinary cortisol test (cushings) next step
high dose dexamethasone suppression test
38
suppressed after high dose dexamethasone suppression test
Pituitary Adenoma
39
Not suppressed after high dose dexamethasone suppression test next test
ACTH
40
Not suppressed after high dose dexamethasone suppression test with high ACTH
non adrenal acth secreting tumore
41
Not suppressed after high dose dexamethasone suppression test with low ACTH
Adrenal tumor
42
tx for 17 alpha hydroxylase deficiency
cortisol replacement, raise as female give estrogen and progesterone, male may want reconstructive surgery
43
tx for 21 alpha hydroxylase deficiency
cortisol replacement, mineralocorticosteroid deficiency, reconstructive surgery
44
tx for 11 beta hydroxylase deficiency
cortisol replacement , antihypertensive
45
MEN 2 mutation
RET protooncogen
46
MEN 1 tumors
Pituitary, Pancreases- look out for zollinger-ellison, Parathyroid
47
MEN 2A tumors
Parathyroid, Pheo, Medullary Thyroid
48
MEN2B tumors
Neurofibroma, Pheo, Medullary Thyroid, look out for marfanoid body