uworld week of 7/27

Question 1

Lynch syndrome cancers

Answer 1

colorectal
endometrial
ovarian

Question 2

FAP cancers

Answer 2

colorectal
desmoids and osteomas
brain tumors

Question 3

Von Hippel Lindau cancers

Answer 3

hemangioblatomas
clear rcc
pheo

Question 4

MEN 1 cancers

Answer 4

Parathyroid
pituitary
pancreatic

Question 5

when to start endometrial biopsy with Lynch?

when to hysterectomy?

Answer 5

30

40

Question 6

RV failure signs

Answer 6

elevated jvp
right ventricle 3rd heart sound
tricuspid regurgitate murmur
hepatomegaly with pulsatile liver
edema and acsities
pleural effusion

Question 7

what dysfunction causes swelling in Cor pulmonate

Answer 7

pulmonary artery systolic pressure cause RV dysfunction

Question 8

TX for asymptomatic PAC’s

Answer 8

nothing but stop drinking, smoking,and caffeine, give BB if symptomatic

Question 9

Bacillary angiomatosis cause manifestation and tx

Answer 9

Bartonella henslae, cats or home less lice), vascular cutaneous lesions(papular, nodular, pedunculate)
organ involvement
fever, night sweats, fatigue
tx: doxy or erythromycin

Question 10

Addisons labs

Answer 10

hyperK, hypoNa, eiosiophillia

high ACTH, low morning cortisol

Question 11

patients with smoke inhalation injury imperically treated with_____ for ____

Answer 11

hydroxycoalbumin or sodiumthiosulfate to tx cyanide toxicity

Question 12

why does cyanide cause met acidosis

Answer 12

reduces oxygen utilization by tissues by binding FE3+ stops ATP

Question 13

why are multiple myeloma patients at increased risk for infection

Answer 13

impaired antibody production after bone marrow infiltrated

Question 14

vitamin deficiency with long term metformin

Answer 14

B12

Question 15

initial tx for hyperventilation syndrome

Answer 15

breathing retraining and reassurance

Question 16

idiopathic transverse myelitis pathophys

Answer 16

immune destruction of spinal cord, often post infectious

Question 17

idiopathic transverse myelitis clinical ft

Answer 17

bilat motor weakness, early flaccid (LMN), late spastic(UMN)
distinct sensory level
autonomic dysfunction

Question 18

idiopathic transverse myelitis dx

Answer 18

MRI T2 hyper intensity

LP: ⬆️ WBC⬆️ IgG index

Question 19

idiopathic transverse myelitis tx

Answer 19

high dose intravenous steroids

plasmapheresis

Question 20

RA patient with nephrotic syndrome

Answer 20

amyloidosis, multiple myeloma also increases risk of amyloidosis

Question 21

tx for sporotrichosis

Answer 21

3-6 months of itraconazole

Question 22

migrane prophylaxis meds

Answer 22

BB
TCA
Topiramate
divalproex sodium

Question 23

which thyroid cancer had increased calcitonin

Answer 23

medullary( the one in men 2 a and b

Question 24

meds for essential tremor

Answer 24

non selective BB like propranalol

anti seizure like primidone

Question 25

polyarthritis rheumatica tx

Answer 25

prednisone, watch for this in older people with elevated ESR and no other inflammatory markers

Question 26

what cancer do people with pernicious anemia get

Answer 26

gastric

Question 27

what are patients with nephrotic syndrome at an increased risk for

Answer 27

atherosclerosis due to hyperlipidemia and av thrombus due to loss of anti thrombin 3.

Question 28

older person holding things far away to read dx

Answer 28

presbyopia, caused by loss of lens elasticity

Question 29

what is telogen effluvium

Answer 29

acute diffuse nonimflamatory hair loss. triggered by illness of stress, treat by addressing underlying cause

Question 30

treatment escalation ankylosing spondylitis

Answer 30

NSAIDS/Cox-2 TNF alpha inhibitors like etanercept and infliximab anti IL 17 like secukinbumab

Question 31

sacrocid electrolyte abnormality sometimes

Answer 31

hyper ca

Question 32

amioderone side effects

Answer 32

``` Brady/❤️ block QT prolongation --> torsades chronic interstitial pneumonitis hyper or hypothyroid hepatitis corneal micro deposits and optic neuropathy bluegray skin peripheral neuropathy ```

Question 33

tx for uric acid stone prevention

Answer 33

potassium citrate to alkalize urine

Question 34

how does sodium bicarb help TCA overdose

Answer 34

Sodium load will stop action on myocardial sodium channels.

Question 35

how does sodium bicarb help Aspirin overdose

Answer 35

urine alkalization increases excretion

Question 36

what test to do before methotrexate

Answer 36

liver function for sure

Question 37

long term cyclophosphamide is associated with

Answer 37

increased incidence of acute hemorrhagic cystitis and bladder carcinoma

Question 38

first tx for cocaine induced chest pain

Answer 38

Benzos, do normal heart attack things except BB if they are having a heart attack

Question 39

ATN casts

Answer 39

muddy brown

Question 40

most common med that causes angioedema

Answer 40

ACE-i

Question 41

what eye thing are storage weber kids at risk for

Answer 41

glaucoma