Diabetes Insipidus Flashcards
What issue occurs that results in DI?
Deficiency/decreased response to ADH
In Nephrogenic DI what occurs?
The kidneys do not respond to ADH
What are some reasons why the kidneys in Nephrogenic DI are not responsive to ADH?
Genetic trait affecting the V2 receptor that affects ADH receptor on the distal tubule
Drugs like lithium
Electrolyte imbalances
In central DI, what two subcategories are there?
Partial - insifficient amount of ADH
Complete - no ADH at all
In central DI what is the issue that brings about DI?
A defect in the synthesis or release of ADH
What are things that may cause central DI?
Head injury
Or surgery near the hypothalamus or posterior pituitary
What is the patho for central DI?
Loss of 80-90% of ADH secreting neurons -> polyuria
What are mnft of DI?
Polyuria
Excessive thirst
Which type of DI can maintain near normal water balance if they gave access to water when thirsty?
Partial Cdi
How is DI diagnosed?
24 hour output
MRI
measurement of ADH serum levels
What is the treatment for DI?
Thiazide diuretics
Desmopressin acetate
What two types of DI are there?
Neurogenic/central
Nephrogenic
