Myasthena Gravis

Question 1

What does myasthenia gravis affect

Answer 1

Communication between the motor neuron and the inner cared muscle cells

Question 2

What is the etiology of myasthenia gravis?

Answer 2

Autoimmunity with an unknown trigger

Possible sensitized T cells

Question 3

What is the patho of myasthenia gravis?

Answer 3

Autoimmunity abs target acetylcholine receptors and bind to them -> less acetylcholine is binding -> muscle weakness and weakened contractions due to less acetylcholine actions

Question 4

Many people with myasthenia gravis also have an abnormal what?

Answer 4

Thymus due to hyperplasia or tumor (large thymus)

Question 5

How is myasthenia gravis diagnosed?

Answer 5

Hx
Px
Anticholinesterase test 
Nerve stimulation
Assay for ach receptor antibodies

Question 6

How is myasthenia gravis treated?

Answer 6

Reversible anticholinesterase drugs
Immunosuppressive therapy
Plasmapheresis

Question 7

What is the myasthenic crisis?

Answer 7

Sudden worsening of symptoms and weakness severe enough to compromise ventilation

Question 8

When does the myasthenic crisis usually occur?

Answer 8

During a period of stress

Question 9

What are mnft of myasthenia gravis ?

Answer 9

Eye muscle weakness
Unstable gait
Difficulty speaking (dysarthria)
Weakness in arms hands legs fingers and neck

Question 10

What is myasthenia gravis?

Answer 10

Autoimmune disorder affecting transmission at neuromuscular junction