5-1 (8.10.16) Flashcards Preview

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Flashcards in 5-1 (8.10.16) Deck (57):
1

define cytoskeleton
-def
-euk or pro

protein framework extending thru cytosol

euk

2

order lengths (short to long)

short: actin
intermediate filament
long: microtubule

3

what protein cross links IMF, MT, A

P-LECTIN

4

"" binds to actin monomers to prevent assembly until filaments are needed

"" proteins (AND nickname) promote assembly

monomer-sequestering protein

nucleating proteins
ARP complexes

5

myosin # occurs in all cells and has one head domain and tail

1

6

REL between myosin and actin

Myosin moves along actin TOWARD plus end.

7

myosin # for muscle

2

8

where else myosin 2 does its contracting thin

contractile bundles and ring

9

what causes contraction of sarcomere

movement of myosin

10

motor molecule, before it can walk, needs to

have its shape changed via hydrolysis of ATP

11

K molecules (FC for name) move to +/- end of MT

what moves to OPP direction

KI-NESIN

+

DY-NEIN moves to MINUS end

12

REL between K and myosin #

REL: similar structure

2

13

K and D are motor molecules on what kind of (MT/actin/IMF)

MT

14

what's the dif bt D and K in terms of structure

K is taller

15

head/tail of motor molecule binds to cargo

tail

16

read: each step of K or D requires hydrolysis of ATP

-

17

cilia's beat does what

moves liquid over epithelia

18

function of "" and "" spokes

converts "" "" into "" ""

Nexin; radial

convert doublet sliding into ciliary bending

19

describe sliding doublet model

something changes about dynein arm -> DOUBLET walks -> nexin and radial spokes prevent from continuing

20

describe primary cilia (structure, 2 things)

LACK dynein arms
don't move

21

describe primary cilia function

-imp in development
-in KIDNEY, are flow sensors

22

dif bt taxol and VV

taxol binds to MT
VV binds to dimer

23

listeria is acquired via (what health behavior)

food poisoning

24

mec of listeria

listeria doesn't have its own actin BUT it hijacks the host cell's ARP complex for actin polymerization and uses this for movement

25

read: immotile cilia syndrome may have situs inversus

-

26

term for on belly

prone

27

if you are moving up and down the body (head to toe direction), what TERM indicates toward head

if you are moving from belly button to back, what TERM indicates the back

superior

dorsal

28

how do you make a sagittal cut

person is laying on his stomach
you take a knife and chop him right down his spine, separating the left and right sides of him

29

above the diaphragm is what
below

above - thorax
below - abdomen

30

name of the model of membrane

fluid mosaic

31

list transport mec across mem (3)

1) diffusion
2) diffusion thru ion channels
3) carrier mediated
-facilitated diffusion
-coupled carrier
-active (pumps)

32

diffusion is only useful physiologically over what

very short distance

33

rate of diffusion is proportional to

concentration gradient
diffusion coefficient

34

diffusion rate in solution can be described by what law

Fick's First law

35

read: direction of flux is from higher to lower conc means + membrane flux

-

36

diffusion of a charged molecule depnds on [ ] AND

electric field effects

37

ex of things that cross via diffusion (4)

02
benzene
urea
C02

38

define osmosis

net flux of water across a semi permeable membrane from area of low solute [ ] to area of high solute [ ]

39

osmolarity vs osmolality

rity = # moles/L
lity = # moles/kg

40

define osmotic pressure

pressure req to prevent osmotic FLOW Of water

41

II = RT(ic)
is eq for

eq is called

where do you get the osmolarity in eq

osmotic pressure

van't Hoff relation

via IC

42

steady state cell V depends on

[ ] of impermeant solutes

43

flow of ions thru channel is driven by what

electrochemical gradient ( [ ] and membrane voltage)

44

which is faster: ion transport or carrier

ion

45

list the classes of ion channels
-light gated is...

1) ligand gated
2) voltage gated
3) stretch gated/mechano-sensitive
4) temp gated
5) light gated (not found in mammals)

46

stretch gated channels exist are involved in what kinds of sensation

auditory

47

transport by ion channels is (active/passive)

passive

48

facilitated diffusion via carriers ( ) depend directly on ATP

does NOT

49

co transport ex (2)

Na and glucose (read: Na is going DOWN gradient while glucose goes UP gradient)

Na and amino acids

50

carriers that rely on an ion gradient controlled by a pump are called

secondary active transport

read: transport of glucose and AA by Na coupled carriers ARE examples

51

define exchange carriers

ex

transport two in OPP direction

Na/Ca exchanger (Na into, Ca OUT against gradient)

52

what's the key pt about active transport

carrier
fueled by ATP

53

Na/K pump maintains what conditions (in and out of cell)

intra: high K, low Na

54

someone wt diabetes -> excess glucose show up in urine bc ??

glucose carriers in kidneys are saturated

cannot transport ALL glucose into bloodstream

55

leaky epithelia transport what

tight epithelia does what

leaky = isosmotic fluid

tight = maintain large osmotic gradient
*renal collecting duct or stomach

56

toxins typically attack what

ion channels

57

dif bt ion selectivity and gating

which channel is this applicable for

s = which ions they transport

g = what causes them to open and close

ION channel