5/21 Flashcards
17 alpha hydroxylase def symptoms
hypertension, hypokalemia (high MR)
low cortisol
feminized if male, lack 2 characteristics if female
21 hydroxylase def symptoms
low BP, hyperkalemia (low MR)
low cortisol
masculinization if female
11 beta hydroxylase def symptoms
high BP, hypokalemia (low aldosterone BUT high 11-deoxycorticosterone)
low cortisol
masculinization if female
glucagonoma symptoms
Dermatitis Diabetes DVT Declining weight Depression
somatostatinoma symptoms
diabetes/glucose intolerance
steatorrhea
gallstones
genes associated with pheochromocytomas
RET, VHL, NF1
tyrosinase deficiency
causes albinism- melanin made by tyrosine in melanocytes
tetrahydrobiopterin deficiency
cofactor for dihydrobiopterine reductase deficiency (converts Phe–>Tyr and Tyr–>DOPA)
PKU (hyperphenylalanine) and low dopamine –> high prolactin
silicosis on imaging
eggshell calcification of hilar nodes and bifringent silica particles
asbestos on imaging
interstitial patter on lower zone
pleural plaques
ferruginous bodies
berryliosis on imaging and histo
nodular or irregular opacities on x-ray
histo: noncaseating granulomas
inhale organic dust on imaging
diffuse nodular interstital infiltrates
noncaseating granulomas
trazodone rare side effect
prolonged boner
methotexate adverse effects
panctyopenia stomatitis hepatotoxicity pulm fibrosis alopecia
receptors that stimulate insulin release
Gq (M3, glucagon)
Gs (glucagon, beta2, GLP-1)
receptors that decrease insulin release
Gi (alpha 2, somatostatin)
beta 1 type of receptor
Gs
daptomycin MOA
causes depolarization of cell membrane by creating trasmembrane channels that cause intracellular ion leakage
inhibits DNA, RNA, protein synthesis
what do the superficial inguinal lymph nodes drain
external genitalia
anus up to pectinate line
what do deep inguinal lymph nodes drain
glans penis, clit
superficial inguinal nodes
what do para-aortic lymph nodes drain
testis
what do the inferior mesenteric nodes drain
descending and sigmoid colon
upper rectum
infants born to hepatits B mothers
mostly always get hep B
are generally asymptomatic
higher risk of HCC and cirrhosis if chronically infected
whats most common cause of death in people with DM
coronary heart disease (MI)
