Test 76: Derm

Question 1

Hansen disease infects what organs

Answer 1

skin and nerves

Question 2

Infection of Hansen disease can be associated with contact with what

Answer 2

Armadillo

Question 3

Difference b/w Tuberculoid leprosy and Lepromatous leprosy

Answer 3

Tuberculoid: Th1 immune
Lepromatous: Th2, lethal

Question 4

Merocrine glands release what

Answer 4

watery security product via exocytosis with no loss of cell membrane

Question 5

Apocine glands secrete

Answer 5

membrane-bound vesicles containing the secretory product

Question 6

Holocrine galnds release

Answer 6

entire content of cells via cell lysis

Question 7

What type of glands are involved with acne

Answer 7

Sebaceous gland which is a type of holocrine gland

Question 8

Exposure to what rays causes photoaging

Answer 8

UVA

Question 9

What happens in photo aging of skin

Answer 9

• epidermal atrophy
• flattening rete ridges
• decrease collagen fibril production
• increase degradation of collagen and elastin in dermis
• increase cross-linking of collagen

Question 10

Axillary lymph node dissection is a risk factor for the development of what?

Answer 10

Chronic lymphadema involving the ipsilateral arm

- predisposes to angiosarcoma

Question 11

Stewart-Treves Syndrome

Answer 11

angiosarcoma

Question 12

What is Cherry Hemangioma

Answer 12

• Benign capillary hemangioma of elderly
• Does not regress
• frequency increases with age

Question 13

What is strawberry hemangioma

Answer 13

• Benign capillary hemangioma of infancy

Question 14

How does strawberry hemangioma present

Answer 14

• appears first few weeks of life
• grows rapidly
• regresses spontaneously by 5-8 years

Question 15

4 year old caucasion male has recurrent skin and respiratory infections. Light skin and silvery hair. Horizontal nystagmus. Peripheral blood smear: giant cytoplasmic granules in neutrophils and monocytes

Answer 15

Chediak-Higashi syndrome

Question 16

Wiskott-Aldrich syndrome

Answer 16

• Eczema, thrombocytopenia

- combined B and T disorder

Question 17

Chediak-Higashi syndrome is a defect in what

Answer 17

neutrophil phagosome lysosome fusion

Question 18

Poison ivy dermatitis produces what in skin

Answer 18

Urushiol

- causes immune response

Question 19

Androgenetic alopecia causes hair loss primarily where on head

Answer 19

anterior scalp and vertex

Question 20

What is the main pathogenic factor for androgenetic alopecia

Answer 20

Dihydrotestosterone (DHT)

Question 21

MOA for Finasteride

Answer 21

5alpha reductase inhibitor

Question 22

Inheritance pattern for androgenetic alopecia

Answer 22

Polygenic inheritance

Question 23

What is used to treat alopecia areta

Answer 23

intralesional glucocorticoids

Question 24

Terbinafina is used to treat what

Answer 24

Tinea capitis

Question 25

Most common metastatic tumors to the brain are

Answer 25

lung
renal
melanoma

Question 26

Melanocytes have what embryologic origin

Answer 26

Melanocytes

Question 27

Bullous pemphigoid

Answer 27

autoantibodies against hemidesmosomes along basement membrane of dermal-epidermal junction

-entire epidermis separates from dermis, forming blister

Question 28

Immunofluresence for Bullouspemphigoid

Answer 28

IgG and/or C3 deposits in linear pattern

Question 29

Bacillary angiomatosis found in what infection

Answer 29

Bartonella Henselae

Question 30

Describe bacillary angiomatosis

Answer 30

Benign capillary skin papules

Question 31

Niacin is derived from what

Answer 31

Tryptophan!!!!!

Question 32

Niacin is essential for what biochemical molecules

Answer 32

NAD and NADP

Question 33

Niacin deficiency can cause

Answer 33

Pellagra: diarrhea, Dementia

Question 34

Arginine is precursor for what

Answer 34

• nitric oxide
• urea
• ornithine
• agmatine

Question 35

Carotene is a precursor for

Answer 35

vitamin A

Question 36

Cholesterol is a precursor for

Answer 36

steroid hormone

Question 37

Orotic acid is a precursor for

Answer 37

pyrimidine

Question 38

PHenylalaine is precrusor for

Answer 38

tyrosine

Question 39

At what sites does splicing occur

Answer 39

GU at 5’ splice stie

AG at 3’ splice site

Question 40

Phemphigus vulgaris

Answer 40

autoimmune against desmosomal proteins

Question 41

Presentation of phempigus vulgarism

Answer 41

• painful flaccid bullae
• spread laterally with pressure
• new blisters may form with gentle rubbing

Question 42

What can cause pyrimidine dimers in DNA

Answer 42

Ultraviolet light exposure

Question 43

Screening for RPR or VDRL, and confirmatory test FTA-ABS is for what

Answer 43

Treponema pallidum