Test 87: All

Question 1

What does human multi drug resistance ( MDR1) gene code for

Answer 1

P-glycoprotein: transmembrane ATP-dependent efflux pump protein that has a broad specificity for hydrophobic compounds

Question 2

Tumor cell lines become resistant after exposure to various anticancer agents. These cells express a specific cell surface glycogprotein that functions how

Answer 2

• ATP-depenent transporter

Question 3

Individuals who are successfully immunized against hep B virus develop protective

Answer 3

anti-HBs antibody

Question 4

Individuals who recover from Hep B infection have what

Answer 4

• anti HBs

- anti- HBc

Question 5

Human epidermal growth factor receptor 2 (HER2) is what type of receptor

Answer 5

tyrosine kinase receptor

Question 6

What drug targets HER2

Answer 6

Trastuzumab

Question 7

drug that is VEGF inhibitor

Answer 7

Bevacizumab

Question 8

MOA for Denosumab

Answer 8

human monoclonal antibody against RANKL

Question 9

What nerve causes weakness perineal musculature causing fecal and urinary incontinence, perineal pain , and sexual dysfunction?

Answer 9

Pudendal nerve injury

Question 10

What is the root for the pudendal nerve

Answer 10

S2,3,4 keeps the penis off the floor

Question 11

Where does the pudendal nerve reenter the pelvis

Answer 11

near ischial spine

Question 12

Masculization of female infant with increased testosterone and androstenedione. Mother has virilization during pregnancy

Answer 12

aromatose deficiency

Question 13

Trauma or sustained pressure to the neck of fibula can cause injury to what nerve

Answer 13

common peroneal nerve

Question 14

MOA for Etanercept

Answer 14

TNF-alpha decoy

Question 15

Elevated systemic blood pressure from alpha1 adrenergic agnonists does what to the heart

Answer 15

• increase vagal tone
• decrease heart rate
• flow AV node conduction

Question 16

Piperacillin-tazobactam is effective against what

Answer 16

• gram (-) enteric rods

- bacteroides fragilis

Question 17

Name Beta-lacatmase inhibitors

Answer 17

CAST

• Clavulanic Acid
• Sulbactam
• Tazobactam

Question 18

Patient’s EKG was irregularly irregular with absent P waves suggetst

Answer 18

atrial fibrillation

Question 19

Bone pain and elevated alkaline phosphatase level in an elderly patient can occur with what

Answer 19

1. osteoblastic metastases

2. paget disease of bone

Question 20

Potter sequence

Answer 20

• renal anomaly
• oligohydramnios
• compression of fetus
• pulmonar hypoplasia

Question 21

What provides the fastest reversal of Warfarin effects

Answer 21

fresh frozen plasma

Question 22

Can you give a patient with INR above 3 warfarin therapy

Answer 22

no

Question 23

What is used for heparin reversal

Answer 23

protamine

Question 24

What does cryoprecipitate contain

Answer 24

• cold-soluble proteins ( factor 8, fibrinogen, von Willebrand factor, vitronectin )

Question 25

Where is water always impeccable in kidney

Answer 25

ascending limb of loop of henle

Question 26

Most common indolent non-Hodgkin lymphoma in adults

Answer 26

follicular lymphoma

Question 27

How does follicular lymphoma present

Answer 27

“waxing and waning” lymphadenopathy

Question 28

Patient with persistent fluctuating lymphadenopathy, who may have had an unrelated pharyngitis ( treated with antibiotics) on initial presentation, most likely has

Answer 28

follicular lymphoma

Question 29

Follicular lymphoma is derived from what type of cell

Answer 29

follicular B cell

Question 30

Translocation for follicular lymphoma

Answer 30

14:18

over expression of bcl-2

Question 31

psoas sign

Answer 31

pain is exacerbated by extension of the hip

Question 32

KRAS is what type of cancer gene

Answer 32

Proto-oncogene

Question 33

type of cancer gene APC

Answer 33

tumor suppressor

Question 34

type of gene BRACA1

Answer 34

tumor suppressor gene

Question 35

Type of gene RB

Answer 35

tumor suppressor gene

Question 36

Type of gene TP53

Answer 36

tumor suppressor gene