BLOOD + GI: VITAMINS

Question 1

VITAMINS: INDICATIONS

Answer 1

• Thiamine, B1 = Wernickes Encephalopathy and Korsakoffs Psychosis
• Folic Acid, B9 = Megaloblastic Anaemia, 1st Trimester of pregnancy to prevent neural tube defects
• Hydroxycobalamin B12 = Megaloblastic anaemia and subacute combined degeneration of the cord
• Phytomenadione, Vit K = NB babies to prevent Vit K deficient bleeding, reverse anticoag effects of Warfarin

Question 2

VITAMINS: MOA

Answer 2

• Organic substances required in small amounts for normal metabolic processes
• SEE INDICATIONS

Question 3

VITAMINS: ADVERSE EFFECTS

Answer 3

• When given IV, phytomenadione + high-dose thiamine = ANAPHYLAXIS
• Most other vitamins preparations are relatively harmless

Question 4

VITAMINS: WARNINGS

Answer 4

• Co-existing B12 + Folate Deficiency = Replace both vitamins simultaneously
• Replacing FA alone -> assoc neurological manifestations of B12 def

Question 5

VITAMINS: INTERACTIONS

Answer 5

• Vit K and Warfarin = antagonistic interaction (intitally desirable)
• When attempting to restart Warfarin, may result in erratic dosing requirements

Question 6

VITAMINS: EXAMPLES

Answer 6

• Folic Acid
• Thiamine
• Hydroxocobalamin
• Phytomenadione