NEURO: ANTICHOLINERGIC - PROCYCLIDINE

Question 1

PROCYCLIDINE: INDICATIONS

Answer 1

• Tx of all forms of Parkinson’s Dx as well as control of extrapyramidal rxns induced by antipsychotic agents

Question 2

PROCYCLIDINE: MOA

Answer 2

• Unknown
• Believed to bind to central cholinergic receptors thus balancing cholinergic and dopaminergic activity in the BASAL GANGLIA
• Procyclidine has an atropine-like action on parasympathetic-innervated peripheral structures including smooth muscle. It’s antispasmodic effects are thought to be related to the blockage of central cholinergic receptors M1, M2 and M4

Question 3

PROCYCLIDINE: ADVERSE EFFECTS

Answer 3

• Dizziness
• Constipation
• Flushing
• Nausea
• Nervousness
• Blurred Vision
• Dry Mouth

Question 4

PROCYCLIDINE: WARNINGS

Answer 4

• blockage of the bladder
• personal or family history of glaucoma (angle-closure type)
• blockage of the esophagus/stomach/intestines (e.g., bowel obstruction)
• severe ulcerative colitis
• certain muscle disease (myasthenia gravis)

Question 5

PROCYCLIDINE: INTERACTIONS

Answer 5

• Pramlintide