RENAL + GU: ANTIMUSCARINICS, GU USE'S

Question 1

ANTIMUSCARINICS, GU USES: INDICATIONS

Answer 1

• Reduce urinary frequency, urgency, urge incontinence in overactive bladder

Question 2

ANTIMUSCARINICS, GU USES: MOA

Answer 2

• Antimuscarinic drugs bind to muscarinic receptors, where they act as a competitive inhibitor of acetylcholine
• Contraction of the smooth muscle of the bladder is under parasympathetic control
• Blocking muscarinic receptors therefore promotes bladder relaxation, increasing bladder capacity. In patients with overactive bladder, this may reduce urinary frequency, urgency and urge incontinence.
• Antimuscarinics useful in treating overactive bladder tend to be relatively selective for the M3 receptor, which is the main muscarinic receptor subtype in the bladder.

Question 3

ANTIMUSCARINICS, GU USES: WARNINGS

Answer 3

• UTI
• Central nervous system side effects (drowsiness and confusion) can be particularly problematic in the elderly and especially patients with dementia
• Angle Closure Glaucoma
• Arrhythmias
• Urinary RTN patients

Question 4

ANTIMUSCARINICS, GU USES: WARNINGS

Answer 4

• UTI
• Central nervous system side effects (drowsiness and confusion) can be particularly problematic in the elderly and especially patients with dementia
• Angle Closure Glaucoma
• Arrhythmias
• Urinary RTN patients

Question 5

ANTIMUSCARINICS, GU USES: EXAMPLES

Answer 5

• oxybutynin
• tolterodine
• solifenacin