RESP: COMPOUND B2-AGONIST-CORTICOSTEROIDS INHALERS

Question 1

COMPOUND B2-AGONIST-CORTICOSTEROID INHALERS: INDICATIONS

Answer 1

• Asthma

- COPD

Question 2

COMPOUND B2-AGONIST-CORTICOSTEROID INHALERS: MOA

Answer 2

• Contain an inhaled corticosteroid to suppress AW inflammation, and a LABA to stimulate bronchdilation

Question 3

COMPOUND B2-AGONIST-CORTICOSTEROID INHALERS: ADVERSE EFFECTS

Answer 3

• Oral thrush
• Hoarse Voice
• They increase the risk of pneumonia in patients with COPD
• Very high doses for a long time systemic adverse efects include adrenal suppression, growth retardation in children and potentially osteoporosis
• LABA = tremors, arrhythmias and muscle cramps

Question 4

COMPOUND B2-AGONIST-CORTICOSTEROID INHALERS: WARNINGS

Answer 4

• COPD with a hs of pneumonia
• Children, with potential for growth suppression
• CVDs, in whom tachycardia may provoke angina or arrhythmias

Question 5

COMPOUND B2-AGONIST-CORTICOSTEROID INHALERS: INTERACTIONS

Answer 5

• Generally not a problem due to low systemic absorption

- Beta blockers may reduce the effectiveness of beta 2 agonists

Question 6

COMPOUND B2-AGONIST-CORTICOSTEROID INHALERS: EXAMPLES

Answer 6

• Seretide® contains fluticasone and salmeterol.

- Symbicort® contains budesonide and formoterol.