NERVOUS SYSTEM + CARDIOVASCULAR SYSTEM: ASPIRIN

Question 1

ASPIRIN: INDICATIONS

Answer 1

• acute coronary syndrome and acute ischaemic stroke, where rapid inhibition of platelet aggregation can prevent or limit arterial thrombosis and reduce subsequent mortality
• For long-term secondary prevention of thrombotic arterial events in patients with cardiovascular, cerebrovascular and peripheral arterial disease
• To reduce the risk of intracardiac thrombus and embolic stroke in atrial fibrillation where warfarin and novel oral anticoagulants are contraindicated
• To control mild-to-moderate pain and fever

Question 2

ASPIRIN: MOA

Answer 2

• Irreversibly inhibits COX to reduce thromboxane from arachdonic acid, reducing platelet aggregation and the risk of arterial occlusion
• Antiplatelet effect occurs at low doses and lasts for the lifetime of the platelet

Question 3

ASPIRIN: ADVERSE EFFECTS

Answer 3

• GI irritation
• GI ulceration and HSRXNs = bronchospasm
• Reg dose = tinnitus
• Life-threatening in OD

Question 4

ASPIRIN: WARNINGS

Answer 4

• Children < 16, risk of Reyes Syndrome
• Aspirin hypersensitivity = AVOID!
• Do not take in 3rd trimester of pregnancy where PG inhibition can lead to premature closure of the DA
• Use with caution in patients with Peptic Ulceration
• Use with caution in GOUT patients

Question 5

ASPIRIN: INTERACTIONS

Answer 5

• May be given with antiplatelet and anticoag drugs in some situations (eg ACS)