RESP: ANTIHISTAMINES

Question 1

ANTIHISTAMINES: INDICATIONS

Answer 1

• 1st line for allergies (hay fever)
• Aid relief of Pruritis and Hives to insect bites or drug allergies
• Adjunct in Anaphylaxis
• Can be used for Nausea and Vomiting

Question 2

ANTIHISTAMINES: MOA

Answer 2

Antagonist of H1 receptor

• Histamine is released from storage granules in mast cells as a result of antigen binding to IgE on the cell surface
• Induces type 1 Hypersensitivity
• AntiH blocks the effects of excessive Histamine release

Question 3

ANTIHISTAMINES: ADVERSE EFFECTS

Answer 3

• Sedation ( H1 receptors have a role in wakefulness)

- Second gen AntiH don’t have this effect as they don’t cross the BBB

Question 4

ANTIHISTAMINES: WARNINGS

Answer 4

• Sedating Anti H should be avoided in Liver Dx patients

Question 5

ANTIHISTAMINES: INTERACTIONS

Answer 5

• NA