RESP: ANTIMUSCARINICS, BRONCHODILATORS

Question 1

ANTIMUSC, BRONCHOD: INDICATIONS

Answer 1

• COPD

- Asthma (adjuvant relief of breathlessness)

Question 2

ANTIMUSC, BRONCHOD: MOA

Answer 2

• Bind to the muscarinic receptor, where they act as a competitive inhibitor of acetylcholine
• Stimulation of the receptor has a wide range of PS effects
• Blocking the receptor: Increase heart rate and conduction, reduce smooth muscle tone, reduce glandular secretions
• Eye = pupillary dilatation and prevent accommodation respectively

Question 3

ANTIMUSC, BRONCHOD: ADVERSE EFFECTS

Answer 3

• Dry Mouth

Question 4

ANTIMUSC, BRONCHOD: WARNINGS

Answer 4

• Angle closure glaucoma patients

Question 5

ANTIMUSC, BRONCHOD: INTERACTIONS

Answer 5

• Not generally a problem due to low systemic absorption

Question 6

ANTIMUSC, BRONCHOD: EXAMPLES

Answer 6

• Ipratropium
• Tiotropium
• Glycopyrronium