Kidneys
Produced urine
Regulate ph, maintenance of blood, produce hormones etc
Whole system is?
Retroparetineal
Ureters
Pass urine from kidneys to bladder
Urinary bladder
Storage of urine
Urethra
Passes urine from the body
Organs of urinary system
Kidneys, ureters, urinary bladder, urethra
Urinary system functions
Regulation of volume and composition and thereby of interstitial fluid and body
Regulation of blood ph by controlling H+ excretion and retention of bicarb
Regulation of blood pressure via the renin angiotensin aldosterone system
Metabolism of: ca++ balance (conversion of vitamin d), rbc formation, gluconeogenesis (occurs in starvation)
*increase volume increase blood pressure, vise versa
Kidney anatomy
Renal sinus
Has the renal pelvis, major calyces 2-3, minor calyces 8-18
Renal capsule
Outside layer
Renal cortex
Outer rim of renal columns
Renal medulla
Renal pyramids
Path of urine drainage
Collecting duct Papillary duct Minor calyx Major calyx Renal pelvis Ureter Urinary bladder
Blood flow in kidney
Kidneys make up only 1% of total body mass but receive 20-25% of blood flow
Our third portal system is located in the kidney
Which vessel is considered the portal vein
Efferent arteriole
Lies between the glomerulus and the pertiubular capillaries or vasa recta
Pathway of blood in the kidney (14)
Renal artery Segmental arteries Interlobar arteries Arcuate arteries Cortical radiate arteries Afferent arterioles Glomerular capillaries Efferent arterioles Peritubular capillaries Perotubular venules Cortical radiate veins Arcuate veins Interlobar veins Renal vein
Nephrons
Functional unit of kidney
Approximately 1 million nephrons, number constant since birth
Damaged ones do not regenerate
Two types cortical nephrons and juxtamedullary nephrons
Juxtamedullary nephrons
Create the vertical osmotic gradient
Salt gradient allows us to concentrate urine
renal corpuscle
Where blood plasma is filtered
Contains glomerulus which is a capillary bed and is surrounded by a glomerular capsule/bowmans capsule
Renal tubule
Part of nephron
Filtered fluid passes through here
Proximal convoluted tubule
Loop of henle
Distal convolute tubule
*nephrons connect to the collecting duct
Where urine formation occurs
Glomerulus
Renal tubule
Collecting duct
Basic steps to urine production
Glomerular filtration
Tubular reabsorption
Tubular secretion
Filtration membrane
Fenestrations in endothelium, stops cells
Basement membrane stops large proteins
Slit membrane/ slit diaphragm stops medium sized proteins
Urine production
Renal corpuscles produce 180 liters of filtrate a day
Plasma volume would be depleted in 30 minutes if we didn’t reabsorb
Reabsorption of most of the filtrate in the tubule
Secretion of wastes into the tubule
Filtration
Occurs in renal corpuscle