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Flashcards in Adrenal disorders Deck (13):
1

Function of glucocorticoids

regulation of intermediary metabolism and immunity

2

Function and example of mineralcorticoids

Aldosterone
Sodium retention
Potassium loss

3

Example of androgens

DHEA

4

What binds Cortisol in plasma and what %

CBG 90%

5

Effects of glucocorticoids

gluconeogenesis and glycogen synthesis in the fasting state.
Increase serum glucose levels/stimulate insulin release.
decreased muscle mass/weakness and thinning of skin.
↑ insulin secretion leading to ↑ in fat deposition.
Catabolic and anti-anabolic effects (Cushing's)

6

Adverse effects of systemic glucocorticoids short term

Secondary infections.
hyperglycemia
mood and behavioral changes

7

Adverse effects of systemic glucocorticoids long term

Osteoporosis.
Cataracts
hypertension
Myopathy

8

Three short to medium acting glucocorticoids

hydrocortisone
Cortisone
prednisone

9

One long acting glucocorticoid

Dexamethasone

10

Addison's disease

Adrenal glands produce too little cortisol
Insufficient levels of aldosterone.
Weakness, fatigue, weight loss, hypotension, hyper pigmentation,
Inability to maintain blood glucose level during fasting.

11

What is the tx for Adison's

20-30 mg of hydrocortisone daily
Supplement with salt-retaining hormone: Fludocortisone.

12

What is Cushing's syndrome

Chronic High levels of cortisol due to ACTH secreting tumor.
Buffalo hump, moon face, osteoporosis, hypertension.

13

What are three medications for Cushing's

Ketoconazole (Nizoral)
Metyrapone (Metopirone)
Mefepristone (Korlym)