Flashcards in Diabetes Deck (18):
What is diabetes
the relative or absolute deficiency of insulin, causing glucose intolerance.
fasting sugar > 126 mg/dL
what are the fasting levels of glucose for prediabetics
what are the sx of diabetes
polydipsia and polyphagia
Unexplained weight loss
what does insulin do
promotes glucose and aa thought membranes of:
cardia muscle cells
What cells are not affected by insulin
What are the features of type I diabetes
Insulin requiring; no natural insulin
Young and thin
Loss of islet beta cells due to auto immune process most likely viral infection.
Ketoacidosis-dehydration. deep labored breathing due to acidosis
What is the term for increase urination
What is the term for increased thirst
What is the term for increased hunger
What are the actions of Insulin:
Increased conversion of aa to glucose
Increased protein synthesis
Increased glucose transport.
proinsulin (small peptide) converted to insulin and protein C
Half life is 3-5 min.
where age Glut-2 receptors found
Where are Glut-4 receptors found
Muscle and fat cells
name of rapid acting Insulin
4 hr duration
name of short acting insulin that lengthens duration
Novolin, often combined with NPH
Peak 2-3 hrs
What is NPH
neutral protein hagedorn.
Delay action due to link to peptide protamide
Becoming less popular
Onset 2-15 hrs,
Duration 4-12 hrs.
What are two background insulin drugs
Glargine; long lasting sustained insulin