Intro to Nervous system Flashcards
What does the axon carry
Electrical signals
What is released from presynaptic terminals
Neurotrasmitters
What neurotransmitter is exclusively excitatory
Glutamate
What neurotransmitter is inhibitory
GABA
What neurotransmitter is both
Acetylcholine
Indirect neurotransmitters act through
intracellular second messengers. Usually takes longer and lasts longer
What are examples of voltage gated chanels
Voltage gated Na+ channels; lidocaine
Wha are examples of ligand gated channel
Glutamate (AMPA)
Nicotinic ACh receptors
What is Metabotropric
they are not directly linked to ion channels
What is ionotropic
Action is immediate and brief
What is an autoreceptor
receptor on an axon terminal through which the neurons own NT can influence the function the the terminal.
Ex; D2 receptor
What is a heteroreceptor
receptors on an axon terminal through which neurotransmitters from other neuronal types can influence the function of the terminal
What are three examples of catecholamines
Dopamine
Norepinephrine
Epinephrine
Cathecolamines are related to
Drugs of abuse
psychiatric disorder
Autonomics
what is DOPA
Dihydroxyphenalanine
What converts Tyrosine to DOPA
Tyrosine hydroxylase
What converts DOPA to DA
Aromatic amino acid decarboxylase
What is the transporter on vesicles
VMAT; Vesicular monoamine transporter
what is MAO
Monoamine Oxidase; breaks down Dopamine (DA)
What is DBH
Dopamine Beta Hydroxylase
What converts DA to NE
DBH
alpha 2 receptor is pre or post
Presynaptic
What are two post synaptic receptors
alpha
Beta
What about serotonin
Not a catecholamine
Sleep
Depression
Migrane headaches
