alcohol Flashcards
(22 cards)
acute effects of alcohol
slows electrical activity in the brain
CNS depression, motor skills impaired, GI, breathing and temperature regulation
areas of brain slowed by alcohol
prefrontal cortex
nucleus accumbens
amygdala
hippocampus
VTA
cerebellum
medulla
aggression and alcohol
pharmacological (inhibits pathways related to judgement and social behaviors) and psychosocial (situational and contextual influences)
chronic effects of alcohol
devastating to almost every organ system in body, especially brain and liver
risks of cancer raise
NTs affected by alcohol
increased GABA inhibitory actions except in reward pathway, blocks glutamate receptors, increases release of dopamine and endorphins in addiction pathways, affects serotonin and cannabinoids
speed of developing alcohol tolerance
single exposure and chronic consumption
rate of metabolism
1 standard drink per hour
binge drinking
5 or more per occasion for men and 4 or more for women
why was alcohol popular and useful for thousands of years
safer than water, calories/nutrition/vitamins, social life built around it, economic trade
physical effects of alcohol
primarily travels to CNS and spinal cord, impacts liver health
zero order kinetics
no matter how much of the substance in the body, it will always metabolize at the same rate
antabuse
medication for people with alcoholism to stay sober, buildup of ALDH when drinking to lead to feelings of discomfort and aversion from drinking
fermented
maximum 15% alcohol, yeast converts sugars into alcohol
distilled
concentrates alcohol evaporation to make it higher percentage
acute alcohol tolerance
single exposure, more intoxication when levels in blood are rising than falling
metabolic alcohol tolerance
body increases production of liver enzymes
cellular alcohol tolerance
change in receptor density for NTs in the brain (GABA and glutamate)
behavioral alcohol tolerance
handle yourself when drunk
cross alcohol tolerance
increases tolerance to BZD and other sedatives
negative effects of chronic alcohol use
liver damage, heart issues, brain damage
alcohol withdrawal
mild: anxiety symptoms
severe: seizures and DTs
delirium tremens
hallucinations, confusion, paranoia leading to cardiac arrhythmias and death if untreated